Any studies showing value of SRT prior to BCR, but not adjuvant ?

How long has it been since yoiur surgery?

BB

I am 21 months out.

Tc,

Yes, I know, that is the next question. With a low PSA, I am thinking that Rt and Ht may be very effective in wiping it out. On the other hand, it may just be wistful thinking.

I have heard conflicting stories on BCR post op. Some imply that the longer it takes for PSA rise, the more likely it is localized in the prostate bed. Other opinions seem to say the opposite.

If I knewvthe answer to that million dollar question, I could make a better decision. If the PC is localized, then the Rt will be effective, and no need for Ht at this time. If however, it has gone systemic, then now or later may not make much difference. Might as well save the Ht bullets for the last non-curative approach, for a few years of extended life.

I am looking for arguments not to pursue Rt now. Will be going to Cleveland Clinic to see what they say, and may go to UMich as well.

Goodlife

Goodlife,  I was able to find a reference to a study that might address your question.  Here is what the author said:

Nielsen(6) said, referring to trials
comparing adjuvant with salvage radiation,
“Since these trials were designed, experts have come
to understand that the results of salvage RT are very
sensitive to the timing of therapy, with the greatest
benefit seen in patients initiating salvage RT at early
PSA rise after surgery. In the context of this evolving
understanding of salvage RT, the trials do not
show that adjuvant RT is superior when delivered in
accordance with the best-available evidence.”

This is a link to the full article:  http://www.prostate-cancer.org/pcricms/sites/default/files/PDFs/Is13-2_p8-17.pdf.

I started SRT at the first sign of a rise and have no regrets.  My thoughts on HT are the same as yours - will start it when I need to.

Carlos