Resistant to radiation pathology?

Some time ago I read on the German PC forum that a more detailed histological analysis of the prostate tissue (that Dr.Bonkhoff does) can show whether the cells are resistant to radiation. I cannot find link to it again. has anyone heard of this? From what I remember Cox-2 was mentioned, whether this is the marker in question, I am not sure.

Thank you Nellie, very good article.

My prior reply had the link within here is a snipet off of it:

Molecular signature of aggressive prostate cancer with risk of systemic
disease
Molecular targeting of prostate cancer
Marker/ Target
Marker Profile Therapeutic Options
Androgen receptor hypersensitive AR ADT3
AR lowering therapies
BCL-2 Positive Taxane, Vitamin E, Aspirin
Chromogranin A (CGA) Positive RP better than RT
Intermittent AB,
Somatostatin-Analoga
Anti-Angiogenetic drugs
(Thalidomid)
COX-2 High expression (2+,3+) Celecoxib
FAS High expression (2+,3+) Orlistat
HER1 and HER2/neu >10% ADT3, Lapatinib
MUC-1 Positive MVA-MUC-1-IL2
PAP Positive Provenge
Somatostatin- receptor Positive Somatostatin-Analoga
Occult metastases Disseminated tumor cells Systemic therapy
Date:
Name:
Signature:
Marker Profile
High proliferation activity (MIB-1)
Severe loss of p27
p53 up- regulation/mutation
HER1 and HER-2/ neu up- regulation
BCL-2
MUC-1
HSP-27
Loss of AZGP1
Loss of PSA, PAP, AMACR
Lympho- vascular invasion (CD34, D2-40)
Occult metastases (Keratins. PSA)
DNA aneuploid

Special-Lady,
perhaps you are thinking about my post in the "German PC forum", where we discuss
Radiation failure and Tumor Markers, NE-Differentiation ect.

Post-130: http://forum.prostatakrebs-bps.de/showthread.php?6240-Strahlen-Resistenz-bzw-Strahlen-Sensibilisierung/page13

This post based on an investigational study from John Concato et.al.

http://www.annals.org/content/150/9/595.full.pdf+html

and some information from an of the leading pathologist here in Germany, Prof.Bonkhoff (Berlin)

http://www.yananow.org/Mentors/BonkhoffStrum.pdf

Hope this helps,
LR

Yeah I couldn' think of that link last night off the top of my head, but it was embedded link in my pathology yananow thing. It is a large file another large file similar is out there by Dr. Rubin.

Amazing what real experts can decern vs. average pathologist.

Thanks LowRoad you know an awful lot for a new poster, maybe you could elaborate????? I am a curious sort. I am getting out the hospital today, so I didn't have my notes with the link, I messed up on the pdf part or something.