You've asked this same question before
Partners Reaction to TIMIX
www.healingwell.com/community/default.aspx?f=35&m=2390117A woman's views on TRIMIX (shipper's wife) - Thoughts from other wives /GF ?
www.healingwell.com/community/default.aspx?f=35&m=2390281The list of options is pretty short.
1) Be honest and up front
2) Be sneaky and don't say a thing
3) Both of the above
4) None of the above
If it's a one night stand - it doesn't matter
If it's a potential long term relationship - she's going to find out someday. I personally would want to avoid getting caught with my pants down so to speak and bring it up before the fist time. Odds are, she's a mature adult and can handle the news.
Since he has to have his meds close by, it could limit the spontaneity of the situation...
What are your friends thoughts on the subject? What does he think would work best "FOR HIM?"