Advanced Prostate Cancer: Therapeutic Sequencing, Outcomes, and Cost Implications

Advanced Prostate Cancer: Therapeutic Sequencing, Outcomes, and Cost Implications
E. David Crawford, MD, & Kyle O. Rove, MD
Published Online: Thursday, February 7, 2013

"Now, practitioners must grapple with the increased complexity of options, indications, cost, patient selection, and side effects, and determine how best to select therapies for patients with varied health statuses and preferences. The Table provides a quick look at these new agents, cost of treatment, and overall survival. This article will briefly examine newly approved treatments for castrationresistant prostate cancer (CRPC), their indications, toxicity profiles, and cost considerations, and evaluate their potential impact on quality of life, prevention of SREs, and overall survival...
The elusive cures for many cancers will be formulated by attacking concurrent pathways using multiple agents."

www.onclive.com/publications/obtn/2013/January-2013/Advanced-Prostate-Cancer-Therapeutic-Sequencing-Outcomes-and-Cost-Implications


Sequencing of Novel Prostate Cancer Agents Is a Work in Progress

Jason M. Broderick
Published Online: Wednesday, December 26, 2012

"Based on his interpretation of the data that are available, Oh summarized the current treatment landscape in prostate cancer (Figure). He also offered some basic principles for sequencing that physicians can follow as they await further results from ongoing trials:

Start with the most effective treatment with the least toxicity.
Switch classes of therapy if there is clear evidence of resistance (eg, hormones to chemo).
Avoid overlapping treatments that may be antagonistic (eg, steroids and vaccines).
Participate in clinical trials whenever possible."

www.onclive.com/publications/obtn/2012/December-2012/Sequencing-of-Novel-Prostate-Cancer-Agents-Is-a-Work-in-Progress/1

Don't forget look at FIGURE for second article on page 2.

Post Edited (HOPENEVERDIE) : 2/8/2013 1:28:13 PM (GMT-7)

So, if I read the chart correctly, if you give them $250,000 they will give you an extra 1.5 years (average) while you suffer serious quality of life issues and endure intensive medical treatment...

I'm going to have to think about that one.....

WOW,
Extremely informative and easy to read..I may have missed something, but I am dismayed to think that practitioners/physicians are making decisions based on cost--I was not aware that accounting was one of their required subject! I read the case study of a 72 year old man with a psa of 80 and a gleason score of 10. If he had annual physicals this should not have happened but I suppose that we can expect this as a common occurrence in light of the "Recommendation"..If Christy lived in Wisconsin, I would vote for him as governor since he outlawed the "recommendation" in NJ._LOL
Bill

Jerry L and All,
When talking to a politician I intend to ask if he had a psa test in the past and if so does he intend to have another..It's a real shame that our president and his challenger-Romney-have both had psa tests along with most of the prominent politicians..I've said enough!!
Bill