This is my first post. I have started Zytiga and prednisone three weeks ago. I have advanced prostate cancer. Right now it appears the Zytiga is not working because during this time (the last three weeks) I have severe bone pain which I did not have before Zytiga. My left hip hurts where I can hardly walk, my back hurts, it's so hard to just to get out of a chair now. My right shoulder hurts to the point where I can hardly reach for anything. My muscles all ache and I even have a pain in the roof of my mouth. My Karmanos doctors here in Detroit are great and I have lived with Gleason 8 prostate cancer for 5 1/2 years. I have a wonderful wife and even with cancer am truly blessed. What I want to know is what is available to me now regarding pain control? I have been taking NORCO 7.5-325. Two pills a day for some time. Of course I'm going to get into a pain management plan at Karmanos eventually. What is available now to help with the pain so I can move around? My Karmanos doctors are all on vacation for a couple of weeks and I may have to tell my family doctor I need something stronger than NORCO for the time being.