Xgeva and Xtandi questions

Hi PreacherMan12,
our experience was with Xtandi first, then Zytiga. I think most of the guys have had the Zytiga first, and if that fails, on to Xtandi, like you. For Mark, the Zytiga did nothing and he felt worse overall. His oncologist OK'd going back to Xtandi even after a doubling PSA and stroke. I think Oncas said that his doc believes that Xtandi may have benefit when the PSA is rising. You were on Zytiga for a year If the Xtandi does not work for you, would your oncol rechallenge with Zytiga? Part of this PC battle is knowing that there is another bullet for you.

You mention that your oncol does not expect much from Xtandi because they are similar. You could say the same for the various HT's. When Lupron fails, odds are that your oncol with try one or two of the newer HT's. Sometimes it works, sometimes not.

Hope you get some meaningful feedback from the guys going through this with you.
Pat

Check the thread from Gizzynme re Jevtana. It sounds like neither are having severe SE's. Mark's oncol did not want to use it because of his already severe weight loss. I understand that there can be overriding issues that prevent using some of the treatments.

You dad is fortunate to have you covering his back!
Pat

tednsal,
You guys have been through a lot! This journey is so up and down and constantly uncertain. My father seems to be delaying the Xtandi for some unknown reason. We have decided to not push. we are concerned that the delay is allowing cont spread but realize it is his time and his decision. We think the SE are causing some doubts - he does not want QOL to diminish though it is with every passing day!

Thank you for sharing. The information gleaned from others is so helpful in our trying to support and know how to support!