Title might be a bit misleading, or not. I have been asking in my other thread with outrageous title about
4 studies which show benefit and whether or not they qualified as RCTs. Instead of waiting a bit longer for answers, I decided to just post a thread claiming it is so and then you guys can correct me if they are not due to some technical something I do not understand.
I'll give the links to the supplement blends in the next in the next post. If they are RCTs they need to be considered in relation to the negative Italian RCT.
But I want to start with the two studies out of MUSC I mentioned earlier. One was men treated with Vitamin D for one year while on AS then re-Bx'ed and compared to men on placebo.
www.ncbi.nlm.nih.gov/pmc/articles/PMC3387395/"Study medication
Food and Drug Administration Investigational New Drug no. 77,839 was granted for clinical studies designed to assess the effect of vitamin D3 (4000 IU/d for 1 yr) on subjects with early-stage prostate cancer. The vitamin D3 (cholecalciferol) was manufactured by J. R. Carlson Laboratories, Inc. (Arlington Heights, IL)............ Clinical trial study design
.................By these criteria, 34% of these subjects progressed (Fig. 2A), defined as an increase in the number of positive cores or in Gleason score; one of the subjects progressed due to an increase in Gleason score (from 6 to 8 in one core), despite a decrease in the number of positive cores (from five to two), and was classified as having had a progression. Five subjects (11%) showed no change. However, more than half of the subjects (55%) showed improvement (Fig. 2B), defined as a decrease in positive cores and no increase in Gleason score at repeat biopsy.....................
Using the same criteria, 63% of the subjects in the control group progressed (because of an increase in the number of positive cores or in Gleason score), compared with 34% in the supplementation group (P = 0.05), as seen in Fig. 3A. Furthermore, in the historical control group, four patients (21%) had improvements in biopsy results"
The other, which has not been fully released yet, treated men with Vit D 4000 IU/D X 60 days prior to RP.
www.acs.org/content/acs/en/pressroom/newsreleases/2015/march/vitamin-d-may-keep-low-grade-prostate-cancer-from-becoming-aggressive.html"In a new randomized, controlled clinical trial, his team assigned 37 men undergoing elective prostatectomies either to a group that received 4,000 U of vitamin D per day, or to a placebo group that didn't receive vitamin D. The men's prostate glands were removed and examined 60 days later.
Preliminary results from this study indicate that many of the men who received vitamin D showed improvements in their prostate tumors, whereas the tumors in the placebo group either stayed the same or got worse. Also, vitamin D caused dramatic changes in the expression levels of many cell lipids and proteins, particularly those involved in inflammation. "Cancer is associated with inflammation, especially in the prostate gland," says Hollis. "Vitamin D is really fighting this inflammation within the gland."
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I contacted one of the authors of this last study to see if a final report had been made. They quickly responded to inform me: "We are still analyzing molecular data (each subject has 20k data points).". So no, the final word is not out. However, I found a video of one of the authors discussing both of these reports which I found very interesting, I hope you will also! ( But someone please tell me if these 4 studies are RCT):
I highly recommend this VIDEO all the way to the end, it is at a minimum interesting:
/www.youtube.com/watch?v=pQ54FG0V7mg&index=7&list=PLLG7h7fPoH8LtUyqg-vxxZO3GlujdfXh6Post Edited (BillyBob@388) : 4/27/2015 2:46:21 PM (GMT-6)