AS guidelines for favorable intermediate--changes?

I've been told that I am between low risk and favorable intermediate (T2a-b, G6, high volume in one half of prostate.

The two doctors with whom I'm considering treatment (either SBRT or HDR) were not real enthusiastic about AS given my volume and relative youth but not wholly dismissive. I'm doing one last scan of AS literature and guidelines before making a decision, and I'm wondering if anyone can point me toward anything recent. I've found a few recent poster abstracts:

http://meetinglibrary.asco.org/print/2132886

http://prostatecancerinfolink.net/2016/01/06/development-of-a-standardized-commercial-test-to-score-patients-as-eligible-for-active-surveillance/

Any thoughts appreciated.  Incidentally, while interviewing these last two doctors I had coffee with our Tall Allen, which was a pleasure!

Jock,

Man, that's a hard one. Currently, am on AS myself, watching closely for just such a condition "change". I would most certainly consider aggressive treatment with a high volume G7. The G6 rating is a curve ball.

For a tie breaker, you might want to get additional biological data on the existing condition. It would verify, or reclassify, the G6 condition by biological markers. If the test reclassifies the condition greater than a G6, you probably should think about the risk at hand. It's the high volume that bothers me.

Test Ref: Mi-Prostate Score urine test (University of Michigan's MLabs).
http://www.mcancer.org/prostate-cancer/screening
__________________________________________________________________________________

OCTOBER 2015
Age: 59
PSA: 3.0 elevated to 3.5 in (6) months
3T-MRI: (1) lesion identified
Fusion Biopsy Results: Lesion cores benign, additional (12) cores = (1) positive, cancer <5%
Pathology Summary: Grade 1 (GS6:3+3), 2nd pathology verification
Cancer DNA Profile: DNA risk status unknown (cancer tissue to small to test, <1mm)
Clinical Stage: T1c
Other Health Conditions: Diabetes Type II (DX 2000), on meds & insulin

PC Treatment: "Active Surveillance"
Risk: Undetected Cancer Progression
Risk Likelihood: LOW

My Story: https://www.healingwell.com/community/default.aspx?f=35&m=3528051

Post Edited (NewDay) : 1/7/2016 9:21:02 AM (GMT-7)

Thanks to all for your thoughts and to TA for the lit dump!