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Posted 7/11/2016 9:53 AM (GMT -5)
So, to me this is even more disturbing than becoming castrate resistant.
I know it's not proven yet, but the possibility. PCa possibly producing it's own andogens....... Hadn't heard of this before, or maybe I just misunderstood the terminology castrate resistant.

http://www.pcf.org/site/c.leJRIROrEpH/b.5801621/k.888C/New_Research_May_Show_Why_Some_Prostate_Cancer_Recurs_After_Treatment.htm
Posted 7/11/2016 11:48 AM (GMT -5)
That is a well-known part of castration resistance. There are several things that go on: the androgen receptor changes and doesn't need androgens for activation, other ligands or no ligands activate or block it, it multiplies on the surface so that it is more sensitive to the slightest amount of androgen, it translocates to the nucleus where it can't be blocked, it makes its own androgens, etc.
Posted 7/11/2016 12:16 PM (GMT -5)
WELL, Not well known to me. My misconception was that once it was CR, then the PCa was "feeding" on something else not producing it's own source of food.

This was mind blowing to me. The former way of thinking gave me hope that another way of blocking PCa would be found. But this way, it's just futile. As that article said, most die 18-24 months after hormone resistance.

Of course the study is 9 years old, much has happened since with treatments. Immuno-therapies .........
Posted 7/11/2016 12:28 PM (GMT -5)
It's a very old study, and a lot has changed since then. Zytiga blocks intratumoral synthesis of androgens, and Xtandi not only clogs up androgen receptors, but blocks their translocation into the nucleus. Other hormonals in development may be even more effective. The discovery of AR-V7 that is Zytiga and Xtandi resistant has led to exploring ways to renew lost sensitivity. The expected lifetime after castration resistance (note the term - it means resistance to castration both physical and chemical, but not to all hormonal agents.) has increased considerably since then.

- Allen
Posted 7/11/2016 9:24 PM (GMT -5)
" As that article said, most die 18-24 months after hormone resistance."

With Provenge, Zytiga and Xtandi, those numbers have been extended considerably...

I really like terms like "most die".....What does that mean?? 51% die? Where does that leave the other 49% ?? What is their prognosis?
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