This is another article discussing the high risk vs. very high risk categorization, but this time based on outcomes from radiation and hormone therapy (there was a
similar article we discussed back in June 2015 here, but based on radical prostatectomy outcomes). It's particularly interesting since that's a more common treatment plan for guys like us.
Unfortunately, the full article has to be purchased to read it. Does anyone here have access to these publications? Particularly, Tall Allen, have you reviewed this one? The abstract talks about
the significant factors, but gives no info about
what the different relative outcomes were.
Very high-risk prostate cancer: Stratification by outcomes of radiotherapy and long-term androgen deprivation therapy.From the article:
Primary Gleason pattern 5, T4 and ≥ 5 or 4 cores with Gleason score 8-10 were risk factors associated with bDFS, cRFS and CSS. Eleven VHR test definitions composed of these adverse factors were associated significantly with bDFS, cRFS and CSS. The final definition was described by primary Gleason pattern 5 or T4 or ≥ 4 cores with Gleason score 8-10 because of the largest sample size of 38% among 11 test definitions. bDFS, cRFS and CSS of the VHR group were significantly lower compared with other high-risk patients (P < 0.001, P < 0.001 and P = 0.015, respectively).