anyone with zometa answers

The side-effects associated with Zometa may not be worth the benefits bestowed...I have been on ADT a long time, taking three 500mg + Vit D calcium pills every day and my latest bone density test was fine...I would not take Zometa unless it's proven that you HAD TO ......But that's just me...

So far I've had ONE certified bone met...I had it treated with SBRT (it was on vertebra T-10) and my last annual bone scan was clean.

You talk to different doctors, you get different answers....

Daughter had breast cancer, was treated with Zometa, her lower jaw fell apart..

What I actually wrote was:

"Early use of Zometa+Celebrex

The hazard ratio found for all metastatic men was:
STAMPEDE: 0.78

The no-brainer here is Zometa+Celebrex. As long as the patient doesn't have contraindications like heart disease or bad teeth, it is cheap, non-toxic, and reduced risk of death by 22% at the 43 month follow-up. Zometa is usually given along with ADT anyway, so it is hard to argue against including this combination along with Zytiga or docetaxel."

So if you're taking Zometa or Xgeva anyway, and you don't have heart problems, why would you NOT add Celebrex to it? The benefit was a survival gain of 22%. It only applies to men with bone mets.

/pcnrv.blogspot.com/2017/06/newly-diagnosed-metastatic-m1-but-still.html

Thank you all for getting back..-fairwind I have 1 met also sbrt that puppy about 2 months back...Break60 ..-looks like you have taken everthing in the book you are doing well with it all. What is the reason your doc put you on zomata class drug I guess what I want to know is what it does .. do I really need it.sitting on a .09 adt2-don't know if or when I need it TA thank you for hot link . that is where I read it before thought it was in a thread wasted a lot of time looking in wrong place. I just don't understand what this drug does for fighting ca heard there was some kind of pill form heard of that??? great day to all NEPOL

I was diagnosed over 3 1/2 year ago with a PSA in the thousands and around 30 extensive bone mets. Besides ADT with Lupron, I got monthly Zometa IVs. After 29 months, backed off to Zometa every 120 days.

Zometa (zoledronic acid) and Xgeva (denosumab) are often prescribed for patients with different types of metastatic cancers and bone mets, in an attempt to help reduce the likelihood bone breaks or fractures, or perhaps more bone mets, from occurring. They may also have some benefit in regards to bones after long term ADT with Lupron or other drugs.

Breast cancer patients on follow-up treatment with Aromatase Inhibitors after surgery can take Zometa too, to possibly help protect bones.

There are injections for the above, called Reclast and Prolia, respectively, usually given less often, by post-Menopausal women who may have osteopenia.

The pill version you might have heard of is called Fosamax (alendronate). Google that, if you wish.
Most Oncologists in the USA will go with either Xgeva or Zometa for advanced prostate cancer metastatic to bones.

Charles

nepol said...
I just don't understand what this drug does for fighting ca

I doesn't do anything to fight cancer on its own. When they tested Zometa alone - it did nothing. When they tested Celebrex alone - it did nothing. But when they combined the two, it had a significant effect.

The reason for it probably has something to do with alterations in the bone's microenvironment.

Do you have bone mets? It doesn't say that in your signature.

There's a limit as to how many characters can go into your signature - take old stuff out and just put in your current situation.

Ok TA I am going to try that in the morning. are you going to tell me what I should do next? I know I am going to be needing some advise trials and such . seems there is something new everyday. I went to see Eric Little in SF you told me of him and another lady ..Eric said my uro. at VA was doing well with my case --stay with him till things got worse. uro passed me over to onc. Eric said he had worked with him (the onco) up in Rredding a long time back but would not go any further . I now know why!!!!

little small I told you I was a country huck. To stay in the VA system and have a good Onc. Vallejo is closest you gave me the name of a lady a Stanford-- they work with VA at Vallejo. I talked to her when I was looking.. she told me to get in at Vallejo and I would see her under VA. don't know how to do that yet --all I have is YOU.. I am going to post lot of vets here maybe I can get some insight on how to pull that off. --- are you going to give me some advise on what to do next-----and do you remember the ladies name? thank you TA . I know I am hard to follow. you have put up with me well NEPOL

Did you mean Sandy Srinivas at Stanford?

Nepol, I am not a doctor. I cannot tell you what to do - I can only make suggestions aout doctors and therapies to discuss with them. I have no idea what you qualify for and what you don't. You have to talk to a good oncologist who is familiar with all the details of your case.