Hormone Depletion Activates Tumor Survival Process in Prostate Cancer, Study Shows

It seems to go against the concept that ADT weakens the cells so radiation has a better chance.

Below I activated the link.

/prostatecancernewstoday.com/2017/09/13/hormone-depletion-activates-tumor-survival-mechanisms-in-prostate-cancer/?utm_source=Prostate+Cancer&utm_campaign=2f83a786ac-RSS_MONDAY_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_a6d9c27ca8-2f83a786ac-71602917

Here's a link to the full text of the study they are talking about: Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer

It's fairly heavy going but there are a few bits that can be understood. It does seem to suggest that starting hormone therapy after radiation -- rather than before -- might have some advantages, but that doesn't seem to be what they propose. Instead, they are interested in adding a PARP inhibitor to the ADT to offset the hormones' tendency to facilitate DNA repair in prostate tumors.

Akai said...
Does this mean patients should not ADT before or during radiation therapy?

Not at all. It just means that PARP inhibitors may make neoadjuvant ADT before RT even more effective. It's just a hypothesis for some future clinical trials.