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Treatment question.
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Prostate Cancer
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alephnull
Veteran Member
Joined : Dec 2013
Posts : 2551
Posted 6/17/2019 10:17 AM (GMT -5)
I know radiation and chemo CAN be used for mets to bones.
But what about
radiation to soft tissue, like liver, bladder, ...etc?
Can it be used or is it generally just chemo?
RobLee
Veteran Member
Joined : Apr 2017
Posts : 1490
Posted 6/17/2019 11:46 AM (GMT -5)
Yes, definitely. I don't know about
the organs you mentioned, because typically there is substantial blood flow to those areas and chemo is quite effective. I know that for head & neck cancers (H&N) such as glossopharangeal cancers, the standard protocol is combined chemo and radiation or "chemorad", which is chemo typically on Monday followed by same day radiation and every weekday thereafter, and repeated every week. You may have seen images of the mesh "mask" that is used to immobilize the head and shoulders for targeted radiation.
For my wife's spinal lymphoma she got one large dose of radiation directly to the primary tumor, then five months of chemo every three weeks. This is typical for DLBCL. Also combined chemo and radiation are often used for breast cancer, though typically not simultaneously.
JNF
Veteran Member
Joined : Dec 2010
Posts : 6097
Posted 6/17/2019 2:17 PM (GMT -5)
I concur and that it is really based on the
location and what the met is doing. If it isn’t interfering with any necessary function, then surgery or radiation usually wouldn’t be used. One of our former members had a tumor that blocked the bile duct causing liver related problems and they did some spot radiation to provide relief and restore liver function. I also remember some men that have had radiation for lung Mets. One with brain Mets was considering whole brain radiation, but I don’t remember that he went through it.
Argent
Regular Member
Joined : Jun 2017
Posts : 111
Posted 6/17/2019 4:53 PM (GMT -5)
I've been out of the business for years but as far as I know just about
any part of the body can be radiated if the hoped for benefit outweighs the risk. For example, if a person had a single met in the liver or lung and nowhere else radiation could be considered. This would be especially true if the person had not had a recurrence for a long time and showed up with a single met. Chemo of almost any type potentiates radiation effects (both positive and negative) because it impairs a tumor's ability to repair its DNA (and some types of chemo impairs the normal tissue's ability to repair also). This is part of the reason that ADT is given prior to RT since there is evidence that ADT impairs prostate cancer cells repair mechanisms.
Fairwind
Veteran Member
Joined : Jul 2010
Posts : 4107
Posted 6/18/2019 9:26 AM (GMT -5)
Lets not forget that your insurance company must agree with and approve this and any treatment,,,Insurance companies frequently balk at treatments they consider to be outside the "Best Standard of Care".....
alephnull
Veteran Member
Joined : Dec 2013
Posts : 2551
Posted 6/18/2019 9:28 AM (GMT -5)
Thanks Guys!!
Two weeks from today (July 2nd) I have my Axumin (fluciclovine F 18) PET scan.
I don't want mets, but this will likely show us where they are at, and so we can maybe finally try to kill this MOFO.
RobLee
Veteran Member
Joined : Apr 2017
Posts : 1490
Posted 6/18/2019 8:05 PM (GMT -5)
alephnull said...
Two weeks from today (July 2nd) I have my Axumin (fluciclovine F 18) PET scan.
Good luck and I hope it can provide some answers.
Bohemond
Veteran Member
Joined : Apr 2012
Posts : 1477
Posted 6/20/2019 11:50 AM (GMT -5)
When I had SRT in 2010 the pre-treatment imaging showed an enlarged lymph node. The MO targeted that node with a portion of each daily radiation treatment, but for only 20 or so days, not the full 36 days of prostate radiation. That was, in his judgment, the maximum he could target at that node without risking damage to adjacent organs.
Pratoman
Forum Moderator
Joined : Nov 2012
Posts : 10056
Posted 6/20/2019 11:54 AM (GMT -5)
Aleph, nothing to add, other than wishing you the best of luck
alephnull
Veteran Member
Joined : Dec 2013
Posts : 2551
Posted 6/25/2019 1:07 PM (GMT -5)
Thanks Prato!!
Seven more days, this has been the longest two weeks in history. They changed it from 6/28 to 7/2.
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