Genetics a poor predictor of risk for most diseases? PCa

Interesting.

The bird's-eye view IMO is less important for us than a closeup on PCa. And here we should distinguish your inherited risk factors (germline DNA testing of your blood or saliva) and what genomics testing can tell you about the actual PCa that you develop (Decipher, OncotypeDx, etc.), which usually looks at your lesions' RNA. Many folks aren't aware that you can download a file of your complete DNA profile for free from any of the major testing sites you've used, like Ancestry.com, 23and Me, etc. and upload it to promethease.com. There, for $12, they will run a medical literature search and give you a very detailed report of your protective and risk factors (e.g., BRCA1 and BRCA2) across all diseases.

The association of BRCA1 and BRCA2 mutations on prostate cancer risk, frequency, and mortality: Systematic review and meta-analysis [2018]

Family history of breast cancer increases the risk of prostate cancer: results from the EPICAP study [2018, Full Text]

Prostate Cancer Incidence and Mortality in Relationship to Family History of Prostate Cancer; Findings from The PLCO Trial [2019]

Genetics of Prostate Cancer (PDQ®) Health Professional Version [Oct. 4, 2019, Full Text]

Germline testing for prostate cancer: community urology perspective [2019]

Germline testing in those at risk of prostate cance [2019]

Germline testing for prostate cancer prognosis: implications for active surveillance [2019]

Djin

I use to think genetics played a bigger role. But recently I found out that my mother contracted radiation poisoning back in the 40s when she worked at Oak Ridge National Labs. She was sick for months. Now, She and 3 of her 6 children have had or have cancer.