HealingWell
Search Close Search
☰

Zytiga vs xtandi

Support Forums
>
Prostate Cancer
✚ New Topic ✚ Reply
❬ ❬ Previous Thread |Next Thread ❭ ❭
Posted 4/29/2020 7:27 PM (GMT -5)
Iam finally starting hormone therapy for recurrent pc in lymph nodes next week. I am undecided on zytiga or xtandi. I don't like the idea of pregnsone with zytiga but I have heard xtandi causes more fatigue. Any thoughts?
Posted 4/29/2020 9:23 PM (GMT -5)
The reason you take prednisone with Zytiga is because Zytiga lowers blood levels of cortisol in many patients. So the prednisone is considered cortisol “replacement”, which can help reduce side effects from Zytiga treatment. It doesn't cause any real side effects on its own. You'll probably only be taking 10mg. Another reason to choose Zytiga is that it is now generic. (abiraterone acetate). Depending on your insurance you could pay as little as $5 per month. Good luck with whatever you choose.
Posted 5/2/2020 9:13 AM (GMT -5)

Hello Stecruz,

We have comrades here who have have been helped by Zytiga, and Xtandi, as well.

This is a question where your doctor will guide you.

I have been on Zytiga for almost 5 years.

I wholeheartedly agree with GoBucks --- if you go with Zytiga, the 2 tiny Prednisone tables are just 5 milligrams, tinier than a baby aspirin, literally.

The newly available generic version of Zytiga can be a consideration, as a cost savings measure.

However, there are now patient cost savings programs set up for BOTH Xtandi and Zytiga.

Consult with your doctor, and talk it through. Both medications have been helpful to our members here, in the past few years, since they became FDA approved.

We have two threads here, with first-hand experiences on both medications, if you need some more insight.

Just use your search feature at the top of your screen and type in either one of these thread topics:

Zytiga: Our Collective Experiences

OR:

Xtandi: Our Collective Experiences

Both threads will give you some "down in the trenches" insight !

Keep us posted, and consult with your doctor, as far as recommendations, as far as your case.

Both of these medications REALLY changed the treatment options for prostate cancer comrades --- including many of our brothers here!

Honestly, it's a HUGE advantage, being able to take a daily medication from home, as opposed to radiation or chemotherapy, which involves ongoing trips to the treatment center.

These medications became FDA shortly before my diagnosis, in quick succession.

These two medications have been a GODSEND to thousands --- just when they needed it most!

Keep us posted --- let us know how you're faring!
Cyclone - # Iowa State University
Posted 5/2/2020 10:16 AM (GMT -5)
There may be reasons that a individual would prefer one over the other, but barring that, I would adhere to the research findings:

Systematic Review of Efficacy and Health Economic Implications of Real-world Treatment Sequencing in Prostate Cancer: Where Do the Newer Agents Enzalutamide and Abiraterone Fit in? (2020 Review)

"Conclusions
No head-to-head studies were found, but we hypothesise that the AA → ENZ sequence may be less costly than ENZ → AA, because time on treatment tends to be longer for a first-line treatment and abiraterone is less costly than enzalutamide. There are indications that PFS of AA → ENZ is superior to that of ENZ → AA, which supports the former sequence as more cost-effective."

[PFS = Progression-Free Survival]

The sequencing studies I've seen found better PFS with Zytiga first, but, if I remember, no difference in overall survival.

Djin
Posted 5/2/2020 12:40 PM (GMT -5)

Djin Tonic,

This research is very helpful and insightful, and will give Stecruz some research to refer to --- based on his original post.

Meanwhile --- I have this "dream" --- a wish --- a vision into the future --- that laboratory scientists might someday combine the powers of XTANDI and ZYTIGA into a combination pill, with SYNERGISTIC efficacy !

KA-BOOM ! KA-POW ! KA-ZAM ! (think SUPER HERO from a comic book)

Now, THAT'S some "BREAKING NEWS" I'd like to see !!!

Thanks for the insightful research!
Cyclone -- # Iowa State University
✚ New Topic ✚ Reply