Enzalutamide

I have been taking Enzalutamide (Xtandi) for 18 months and have had no specific side-effects I can attribute to the medication.

I think there is reason to believe there Could be similar side-effects for Enzalutamide and Apalutamide because they are similar medications with similar modes for reducing Testosterone availability.

DeeBee,
As they say, Welcome to the club nobody wants to belong to...
I was on Zytiga for 19 months, then when PSA started back up (from 0.4 to 2.7) I switched to Xtandi. Still on Lupron and xgeva (for bone mets) and SE's with Xtandi seem a little worse than Zytiga in two areas: fatigue and night sweats. I'm working full time from home, getting regular exercise with 3-4 long walks each week, but those walks (approx 3 miles each) seem tougher. Whether that's Xtandi-related or just being in Year 4 of all these treatments not sure. But for me, what's most disappointing is that Xtandi doesn't appear to be working. PSA from 2.7 - 7.2 in 4 months. NOT to say it won't work for you--plenty of brothers here have had great results with it. But you read enough of the posts here and you get just how unique everyone's situation, PC, and physiology really is.
I also consult with two very different onco docs, and if that's possible I highly recommend it. That team often comes up with the same answers--other times they do not, often presenting me with an offensive vs defensive strategy. (And I almost always play offense...)
This is a journey. Keep the faith.