Concurrent antiandrogen therapy in the SRT setting for recurrent PCa

Concurrent antiandrogen therapy in the salvage radiotherapy setting for recurrent prostate cancer: a literature review (2024, Full Text)

"Abstract
Radical prostatectomy is widely used to treat localized prostate cancer; however, 20-50% of patients will experience disease progression despite surgical management. Management of these patients involves salvage radiotherapy (SRT), which has variable efficacy ranging from cure to disease progression in roughly 50% of cases with aggressive prognostic factors. Based on the success in combining antiandrogen therapy (AAT) with definitive radiotherapy for prostate cancer, it has been suggested that the addition of AAT may benefit patients receiving SRT. Here we review the literature surrounding the rationale for AAT in this setting and synthesise the results of several key trials assessing the benefits of AAT within the SRT setting."

Introduction
--Biochemical recurrence after prostatectomy and salvage radiotherapy
--Antiandrogen therapy
Antiandrogen therapy in the salvage radiotherapy setting
--Overview of the literature
Discussion
--A word on outcomes
--Synthesis of the evidence
Future Directions
References [68]

Post Edited (DjinTonic) : 11/23/2024 2:36:12 AM (GMT-5)