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Posted 1/22/2015 12:29 PM (GMT -5)
Wonderful!

http://medicalxpress.com/news/2015-01-viruses-unexpected-role-inflammatory-bowel.html

immune system and gut bacteria

http://medicalxpress.com/news/2015-01-immune-digestive-health-fostering-good.html

Old Mike

Posted 1/22/2015 12:44 PM (GMT -5)
That virus thing is really interesting! If it is viruses, it sounds like it could be pretty tricky to treat, but just knowing what the cause is would be huge!
Posted 1/22/2015 12:50 PM (GMT -5)
but it makes more sense that changes in the virome are a consequence and not a cause of UC
Posted 1/22/2015 1:06 PM (GMT -5)
I have been wondering how long it would take for someone to start researching the virome as well.
Posted 1/22/2015 1:06 PM (GMT -5)
Well, those were extremely fascinating, the first one in particular. I first came down with UC while I was in the hospital being treated with broad spectrum antibiotics for an unknown infection which later (after the fact)was determined to be Mono (EBV). My GI problems were chalked up at the time to being short term effects of the antibiotics and they put me on Florastor as soon as my problems started. It was assumed that shortly after my course of antibiotics was finished that my GI problems would resolve. Of course they didn't and I was diagnosed with UC.

about the first year of my disease I blamed my UC on the EBV virus and found medical articles to back up this theory. EBV is untreatable. After the first year I began to concentrate my blame on the antibiotics instead of the EBV as there is much evidence on this as well. This article has me rethinking a little bit now. It could also be a combination of less diversity of the Microme and increased diversity of the Virome.
Posted 1/22/2015 5:43 PM (GMT -5)
Very interesting and could lead to some very important findings. But this just takes one of the most complex systems in the body (the microbiome) and makes it exponentially more complex.

Do the viruses shape the composition of the microbiota by actively killing bacteria? Do they integrate into the host genome and change certain bacteria such that they grow better or worse?

I think one of the most interesting things is that there are viral genomes that are unknown to us. Its a very very long shot, but maybe one of these could be the cause of the disease. It doesnt explain a lot (i.e. why its starts distally, why there is a north-south gradient, why it only recently developed, why it affects certain age groups, etc) but it could be a factor.
Posted 1/22/2015 10:49 PM (GMT -5)
When I got my first flare in postpatrum, my post natal nurse, actually told me to get checked for virusus in stool culture. She beleived there is virus connection to diesease specially if you do not have family history. She also said if you could ask doctor to prescripe flagyl or some anti viral medication to check the symptoms are diappering before doing colonoscopy. But my GP refused to prescribe anything without correct diagonising.
Posted 1/22/2015 11:03 PM (GMT -5)
@sweety: testing stool for virus is much more difficult than testing for bacteria. the most logical thing would have been to check for c-diff bacteria. flagyl and vanco are serious antibiotics and without a diagnosed infection, it would not have been responsible to prescribe them. also, antibiotics to not do anything to virus.
Posted 1/23/2015 12:15 AM (GMT -5)
yaa DB you are right. But she suggested some antiviral meds which I dont remeber. But she said flayl may help too.
Posted 1/23/2015 6:02 AM (GMT -5)
That is so refreshing to read and understand and at the same time knowing people are kicking it up a level and making some forward progress in this IBD area instead of going in the same circular relationships over and over again.
Posted 1/23/2015 6:47 AM (GMT -5)
I will add this one, also not good.

Old Mike

http://discover.umn.edu/news/science-technology/people-may-inherit-gut-bacteria-cause-crohns-disease-and-ulcerative-colitis

Posted 1/23/2015 9:37 AM (GMT -5)
When I thought that the EBV virus was causing my UC I researched taking antivirals but most of my research seemed to indicate that that would actually make me worse.
Posted 1/23/2015 1:37 PM (GMT -5)
Gary... Interesting I have also had EBV and our ubiome results were similar.

I'm glad researchers are looking into all aspects of gut make up. Hopefully one step closer. Very interesting.
Posted 1/27/2015 6:25 AM (GMT -5)
A little bit more specific info on the above, just came out.

Old Mike

http://www.ncbi.nlm.nih.gov/pubmed/25619688

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