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Article: ‘Mono’ Virus Linked to Seven Serious Diseases including IBD

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Posted 4/19/2018 7:31 AM (GMT -5)
‘Mono’ Virus Linked to Seven Serious Diseases
Epstein-Barr Virus Affects Health in More Ways Than Known
Monday, April 16, 2018

A far-reaching study conducted by scientists at Cincinnati Children’s reports that the Epstein-Barr virus (EBV)—best known for causing mononucleosis—also increases the risks for some people of developing seven other major diseases. Those diseases are: systemic lupus erythematosus (SLE), multiple sclerosis (MS), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), inflammatory bowel disease (IBD), celiac disease, and type 1 diabetes. Combined, these seven diseases affect nearly 8 million people in the U.S. Study results were published today in the journal Nature Genetics.

The study shows that a protein produced by the Epstein-Barr virus, called EBNA2, binds to multiple locations along the human genome that are associated with these seven diseases.

Overall, the study sheds new light on how environmental factors, such as viral or bacterial infections, poor diet, pollution or other hazardous exposures, can interact with the human genetic blueprint and have disease-influencing consequences.

/www.cincinnatichildrens.org/news/release/2018/mono-virus
Posted 4/19/2018 9:16 AM (GMT -5)
Very interesting. Thanks for posting.

Hands up how many of us on here had mono (aka glandular fever for those in the UK) (or rather than had a severe enough case to know it was mono/glandular fever)? I did not.

I would add, however, given 90% of the population has been infected with EBV, there's some other reason why those 7 diseases are on the rise nonetheless. EBV has been around along time and is very common.

Post Edited (FSLondon) : 4/19/2018 8:53:45 AM (GMT-6)

Posted 4/19/2018 11:58 AM (GMT -5)
EBV has been around along time and is very common

Yes, EBV has been around long enough to have evolved into causing diseases that years ago were not very common.
Posted 4/19/2018 12:13 PM (GMT -5)
Points toward epigenetics, which is something I think might cause this crapfest we call UC. Essentially, UC develops later in life for the vast majority of us, and something changes our genetic expression that triggers the cascade of awful events that lead to an UC. This article talks about one example of it, and says other things beyond EBV could as well: pollution, crappy diet, etc.
Posted 4/19/2018 1:14 PM (GMT -5)
I believe risk means trigger the responses since all are autoimmune..... but herpes viruses have been around forever and last forever in the body.

I've never had Mono, but when I see the Rheumy in May, I'll make a list of questions regarding testing.

q
Posted 4/19/2018 3:21 PM (GMT -5)
Similarly I wonder how many have had a tick bite, even if they don't test positive for Lyme? I test positive only for IgG P41 Ab. on the Western Blot test. My doctor says one positive is not considered Lyme. It means that I have been infected by a flagellate, possibly Borrelia, possibly something else. Having travelled in Central and South America it could be anything, but I also did have a tick bite with the bullseye about 12 - 14 yrs ago. I think it may have triggered/still be triggering my immune system. fwiw, my GI is not interested...
Posted 4/19/2018 8:33 PM (GMT -5)
Lets see got mono in Korea 1971. UC 1980 after quitting smoking in 77.
with mono lymph glands in my neck were huge, immune system did not like it.
Took about a month to recover.
Or was it the Agent Orange,we also got exposed in Korea.
Oldmike
Posted 4/20/2018 7:05 PM (GMT -5)
I had mono in high school but that was a long time (almost 30 years) before getting a UC diagnosis. I had good health before UC at age 46 except for bad pollen allergies. Never smoked so never quit which I know caused UC to a subset of people.

We need a Venn diagram to draw conclusions about correlated things to UC because a correlation to mono may be coincidental.
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