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Which Came First PSA or UC?!

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Ulcerative Colitis
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Posted 7/16/2018 7:41 PM (GMT -5)
Does anyone that has both PSA and UC wonder what came first? After years of psoriasis on my body it cleared up. 7 years later I was diagnosed with UC ( pancolitis ) and three months later Psoriatic Arthritis. Both GI & Rheumatologist day there is no way to know and it really doesn’t matter as they are both auto immune and inflammation can appear anywhere. The biologics were treating both which was a blessing, however antibodies were developed to Remicade, Cimzia and after two years Humira. So I am now on Entiviyo which only treats UC and 60 ml weekly injection to keep the PSA quiet and the results? I am a walking zombie who is in bed at 7PM EVERYNIGHT. After 4 years of following doctors directives I am honestly ready to stop it all.
Posted 7/16/2018 10:37 PM (GMT -5)
I don't know about PSA, but some studies have shown a link between psoriasis and IBD, but none that I have read indicate which comes first for people. My dad's family has psoriasis (hence my curiosity -- gotta blame someone! :turnsmile, though I do not, and the studies also suggest a genetic predisposition for IDB in those with first degree family members with psoriasis. I think it's really hard to figure out what comes first with our diseases. I have a different AI skin disorder (hidradenitis suppurativa) and I know I developed that way before UC and in high school.
Posted 7/17/2018 7:42 AM (GMT -5)
Sometimes we can get autoimmune disorders in 2's, 3's, etc. I do not think there is any rhyme-or-reason to it. You get one illness, a number of years later it is possible to get another, and so on. I do not think one specific illness is always the 1st, rather any illness could be.

Could Stelara or Xeljanz treat your other immune conditions? They are approved for UC.

Often, an immunomodulator like azathioprine/imuran/6MP is taken concurrently with biologics to reduce the likelihood of antibody formation. Ask your doctor about that.
Posted 7/17/2018 6:21 PM (GMT -5)
It is all related, because they are autoimmune illnesses. I was having difficulty getting a diagnosis of IBD from my GI, so I said heck with it, and have been seeing a rheumatologist for the ankylosing spondylitis (arthritis) that is associated with it. If I get the diagnosis, the treatments are usually the same as for IBD. I like seeing the rheumatologist much more, and I feel like they are much more competent at dealing with systemic autoimmune illnesses such as these. I hope I never have to see another GI again! I had allergies first, which is another autoimmune disorder.

Post Edited (Handyman123) : 7/17/2018 5:28:04 PM (GMT-6)

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