I have my scope scheduled for Tuesday morning. My prep is Pico-Salax. I was reading the instruction and it says to drink the first package at 17:00 and second one at 22:00. I really don’t want to run to the bathroom overnight. Should I go with what it says or can I just take the first package at 12:00 and second at 17:00?

I just did the Pico prep, and always have really. Except they add two tablets of Ducolax with each Pico drink. Anyway, the trick I have found for me over the years is right after the first Pico, I drink as much as possible and then some more. Water and apple juice usually. about double what they suggest ~3-4 liters.

Then when the second dose comes up I do the same, but I find the urge for a bowel movement only lasts an hour or two as there's nothing left really. Clear sleeping after that.

So you would get to bed maybe around midnight if it worked for you. However I guess like meds, everyone is going to be different. But I would still budget 2-3 hours of time before being able to get to sleep.

I'd be worried taking it early might result in not so clear of a colon for the pictures, but who knows really - might be worth a call to your GI to ask at least.