So sorry to hear about your grandmother. May your memories of her bring you comfort.

Is your sig correct? You are on Entvio every 4 weeks after getting antibodies? If so, it sounds like it may have lost effectiveness. You probably should talk to your doc about changing meds. Remicade, Stelara or Xeljanz are options.

Do you have a fever at all? You could have picked up a bug. You should call your doc. He may want to do a stool test.

CCinPA, my signature is correct except that I am currently on hydrocortisone instead of prednisone. I started going to an Endocrinologist because of horrible symptoms from suspected secondary adrenal insufficiency. I had made it down to .3 equivalent to pred, but have had to go back to .6 mg equivalent to pred because of the stress. I always have worse GI symptoms when my body is struggling with low cortisol, so I am trying to be patient to see if some of this settles down in a few days, though yesterdays 12 times doesn't make me feel optimistic. I know my GI has told me before he would try xeljanze next if Entyvio stops working. I also know his first step is pretty much always a stool test, though I am confident it will be negative.

Countess, I am extremely reluctant to do a course of Pred. I haven't had a Dexa in about two years, but I had osteoporosis from the Pred, and the illness from the adrenal fatigue has been as debilitating as flaring badly. That and even when I was on 40 mg of pred, I had pretty significant symptoms. Puzzled my GI. Did you get out of your flare from just doing that short course of Prednisone? Glad Remicade mostly works for you.

Yes spring you do have options and at least with Xelanz you don’t have to venture out for infusion . Remicade has been very good to me and yes the 20 day pred course did the trick so far anyway. I’ve been off pred for a week now. Please keep us posted.

Ya know I have a friend on entyvio every 4 weeks and she always complains of feeling like a truck has run over her. She first thought it was from weaning prednisone and now I was concerned she might have lupus . Did you have low grade fevers at times too? I’m starting to wonder if it’s the entyvio itself. She gets joint pain and fatigue

Update. Thankfully my flare has really gotten a lot better. I am back down to close to normal, though still seeing some mucous. I had my infusion yesterday, and also saw my GI. I had to go back up on the hydrocortisone. Basically I don't deal with stress well, and the hydrocortisone helps manage that. Told me to stay at that dose until I don't see mucous. 7.5 milligrams total, which is like 2 mg of Pred. I have a DEXA scan Friday. I feel like I am going to the dentist and I am going to hear how I failed. My last one was 2 years ago and showed osteoporosis and osteopenia.

I’m glad you’re feeling better, sometimes I wonder about the almighty power of stress.