Azathioprine dosage

I think I started on 50mg, then 75, then finally 100mg/day for the last ~10 years, which has kept me out of a flare for 5+ years.

I weigh around 180 pounds. People on here tell me that's still a lower dose for my weight.

Over the last couple years I have been prone to bad infections, sinus infections, staph infections in skin, and a case of shingles while in my mid 30s. But not having flares makes that bearable so far.

Azathiopurine is a weight based drug, so impossible to answer your dose without knowing it.

Basic formula is be within the range of 2.0 to 2.5 mgs of azathiopurine for every kilogram of body weight. For example if you weigh 150 pounds (70 kilograms) then it'd be:

2.0 mgs x 70 kgs= 140 mgs of aza per day

2.5 mgs x 70 kgs = 175 mgs of aza per day

The second important dosing factor is your bloodwork. Some cannot safely get to the above mentioned dosing without inadvertently getting Hepatotoxicity. So they're gasteroenterologist keeps them at a lower dosage for safety.

50 mgs of azathiopurine daily isn't within that range unless you're concurrently on allopurinol due to Hepatotoxicity.

I weigh 100 pounds and take 100 mg of Imuran a day. I get regular blood work to make sure that my liver function is good and that my white blood cell count is in the normal range. The accepted does to treat uc is 1.5-2.5 mg per kg. I started at 50 mg for a few weeks then went up to 100mg. I also had a TPMT done before I started taking it to make sure I was a good candidate for the drug.