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58% of IBD biologic patients with positive covid19 serology had no symptoms

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Ulcerative Colitis
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Posted 11/29/2020 10:30 PM (GMT -5)
An interesting one, they checked blood serology for IBD patients on biologics to check for exposure to covid19 (presence of Antibodies against covid19). 58 percent who had been exposed had zero symptoms.

Asymptomatic Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Patients With Inflammatory Bowel Disease Under Biologic Treatment

Source:. https://www.gastrojournal.org/article/s0016-5085(2035117-9/fulltext

"More than half (58%) of patients with positive SARS-CoV-2 serology results were completely asymptomatic during LD, and the others reported only mild symptoms. All biologic treatments were safely administered, even at high doses for the induction of remission. In this cohort, immunosuppressive treatment did not affect SARS-CoV-2 infection outcome.

Preliminary data suggest that immunosuppression is not an additional risk factor for the development of severe forms of SARS-CoV-2 infection, because it was also shown for the previous coronaviruses pandemics, SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome).4"
Posted 11/30/2020 4:43 AM (GMT -5)
Thanks ipoop, interesting.
Posted 11/30/2020 9:32 AM (GMT -5)
Seems our outcomes (all IBD patients regardless of meds) is better overall. We also have a lower mortality rate, even after adjusting for age (as IBD patients tend to be young). We're not invincible, there are mortalities and hospitizations. But I generally feel better than I did initially in March.
Posted 11/30/2020 12:00 PM (GMT -5)
It's nice to see good news! Most of the time we are higher risk. The secure IBD database created a risk calculator based on the date from 3,000+ people with IBD who had COVID. It takes into account, age, meds, gender and other medical co-morbidities. If you are on biologics, the risk is lower than on other meds.

https://covidibd.org/covid-19-risk-calculator/
Posted 12/1/2020 2:34 AM (GMT -5)
With only a 19 patient sample size, this could easily just be a fluke and mean nothing. Will be interesting to see larger, more significant studies.
Posted 12/11/2020 9:10 AM (GMT -5)

Jane974 said...
It's nice to see good news! Most of the time we are higher risk. The secure IBD database created a risk calculator based on the date from 3,000+ people with IBD who had COVID. It takes into account, age, meds, gender and other medical co-morbidities. If you are on biologics, the risk is lower than on other meds.

https://covidibd.org/covid-19-risk-calculator/

Thank you for the link to the calculator. Had to smile at this one. I just put my details through the calculator (I'm in the UK) and then tried it with different country of residence out of interest and it gave me very different risks according to country of residence. I don't have time to dig in to now about how they weight country but I'm very curious now.

Country of residence marked UK: Estimated probability of hospitalization or death given infection: 28.5%
Country of residence marked Germany: Estimated probability of hospitalization or death given infection: 18.8%
Country of residence marked US: Estimated probability of hospitalization or death given infection: 10.5%

Even bigger variation looking at death risk only with US based coming up as 0.7% and UK based 3.2%
Posted 12/12/2020 5:14 AM (GMT -5)
Haha, that's a fun tool! The way it varies with country shows all the biases, namely it depends on the rate at which a country performs covid tests and uploads the ibd patients data onto the website
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