Studies on aspirin

I've been reading so many positive things about preventative aspirin use, I couldn't possibly list them all. Unfortunately, it's not recommended for people with IBD. Yet I am having trouble finding some clear studies on this.

Is there anyone here who has an actual research article talking about this? I don't want to read webMD type sites that talk about it in general, but actual studies. Why does aspirin harm IBD patients and what is the mechanism?

Aspirin seems to cause diffusion of H+ ions accross the gastric barrier. That creates physical erosion, and prolonged platelet bleeding. Of course taking aspirin sporadically isn't really a problem. But long term use can be for some. IBD patients are more prone to bleeding so are advised against long term aspirin.

Quincy is right, mesalamines (5-ASA) and aspirin are not the same. Aspirin can cause internal bleeding while 5-ASAs are anti-inflammatory for UC. But they are related.

Mesalamines are derived from Salicylates which are found in some plants such as white willow bark and wintergreen leaves. Aspirin is also derived from those salicylates which have been used for its health benefits for at least 2,400 years.

https://www.ncbi.nlm.nih.gov/pubmed/24710620
5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis:
Results:
Seventeen studies containing 1,508 cases of colorectal neoplasia and a total of 20,193 subjects published from 1994 to 2012 were analyzed. 5-aminosalicylates use was associated with a reduced risk of colorectal neoplasia in patients with ulcerative colitis (OR 0.63; 95%CI 0.48-0.84). Pooled OR of a higher average daily dose of 5-aminosalicylates (sulfasalazine ≥ 2.0 g/d, mesalamine ≥ 1.2 g/d) was 0.51 [0.35-0.75]. Pooled OR of 5-aminosalicylates use in patients with extensive ulcerative colitis was 1.00 [0.53-1.89].
CONCLUSION:
Our pooled results indicated that 5-aminosalicylates use was associated with a reduced risk of colorectal neoplasia in patients with ulcerative colitis, especially in the cases with a higher average daily dose of 5-aminosalicylates use.

yes, that's true, I used to play truant from school and had the lowest possible notes in Chemistry - the effects are visible

Just clarifying Ewa's comment.

ASA...aka aspirin... not used in IBD meds because it can cause digestive bleeding. Other salicylates are used.
q