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Calproctecin query

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Ulcerative Colitis
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Posted 7/28/2022 5:12 AM (GMT -5)
How quickly does you cal pro rise if you go into a flare. Is it a slow burner gradual increase or can it shoot up to a large number pretty quickly?

Thank you
Posted 7/28/2022 10:00 AM (GMT -5)
Calprotectin generally rises in advance of symptoms
Posted 7/28/2022 10:38 AM (GMT -5)
Does it respond quite quickly, or is it a slow burner. Mine has moved from 35 to 580 over 3 weeks and my PCP said this must be lab error as I am not showing symptoms
Posted 7/28/2022 11:51 AM (GMT -5)
It doesn't respond, it's a protein that's released when there IS inflammation. It often increases before you show any symptoms. And yes it can go up that quickly.

I would trust the lab over your PCP but if you've been taking NSAIDs that can make the level go up in the absence of a flare.
Posted 7/28/2022 11:54 AM (GMT -5)
One other thing, the levels can fluctuate a lot within the course of a day. Generally the levels are highest first thing in the morning (assuming you haven't been pooping during the night). Therefore if you want to get a consistent picture of what's happening you should always take the sample in the same way (I always take it from the first poop of the day).
Posted 7/28/2022 4:14 PM (GMT -5)
Mine doesn't rise before symptoms usually. I often have very bad symptoms and my calpro is still low.
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