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Tulisokibart, a new monoclonal antibody

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Ulcerative Colitis
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Posted 10/20/2024 10:08 PM (GMT -5)
In recent months Microsoft News has been displaying articles from Medical Xpress that summarize current research projects on UC treatment. I've seen interesting reports from Vienna & Aalborg University in Denmark lately. Now today they posted about a promising new targeted treatment by monoclonal antibody Tulisokibart (formerly called PRA023) that's being studied at the Cedars-Sinai IBD research center in Los Angeles. Apparently the researchers there have just published a related article in the New England Journal of Medicine. They're excited about this potential treatment for moderate to severe UC because it might be an early intervention without side effects that stops inflammation and therefore prevents fibrosis of the gut tissue that occurs with long-term UC. They expect to start a Phase III study involving over 100 subjects from multiple countries soon. / Old Hat (40+ yrs with left-sided UC; in remission taking Colazal)
Posted 10/21/2024 1:16 AM (GMT -5)
This new drug candidate was developed by Prometheus Biosciences, a company founded in San Diego by some gastroenterologists and associates from Cedars-Sinai (Los Angeles) along with some researchers and biotech people in San Diego.

Although it's a different company than Prometheus Labs, the similar names should be a clue to readers that the companies are closely related, with many of the same principal people involved.

Merck bought out Prometheus Biosciences last year (2023) for about $10.8 billion based on the promise of this new treatment.
Posted 10/21/2024 2:37 PM (GMT -5)
Good to get your input on this, Beave. Also your comment on Avsola a few weeks back for new forum member Rascle. Apparently the doctor also gave him Azathioprine at some point then itching became a disturbing side effect so he still could benefit from your advice. / Old Hat
Posted 10/21/2024 7:43 PM (GMT -5)
Thanks, Old Hat ... always good to hear about potential new drugs.

I really wish they would develop a blood test that could predict what class of drugs would work best. I had an old doc tell me that he thought there would be one within 10 years. That was 5 years ago, so hopefully there will be one soon and we can all stop having to go through trial and error until we find what works.
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