Histamine intolerance Gary? Pathogenkiller?

MCAS is mast cell activation disorder, where your mast cells are normal in quantity and shape etc but are hyper-sensitive.

You have to supplement b12 with the RIGHT kind of folate. That is imperative.

Bookworm, You have oral allergy syndrome and are reacting to the pollen on the outside of the fruit .. But when you cook it, it destroys the pollen. Your body produces histamine as a response to a trigger. Killcollitis's dd likely has a full tank of histamine floating around in her body from the gradual build up due to the small amounts of naturally occurring histamines in histamine rich foods that she can't clear.

Killcollitis, I do nothing but research all this crap every spare minute I have. Heh. CBS is hard because you have to get the ammonia in your body down as you slowly open mthfr. You have to treat CBS first before mthfr.

Ive got the name of a doc in ca who is a yasko protege that will do phone consults. I asked earlier if she was sensitive to sulfites because of CBS.. if you think she has that, you gotta try treating it first. Ill try and help you if you cant make sense of it.. let me know.

It sucks having to do all of this basically on your own. Im very thankful for the internet.

Honestly, I wouldnt worry about CBS.. but everyone screams you must treat it first eleventy111!!!!1 So I have to repeat that. Rich Konyenberg did studies where if you treat with his 5 supplement simplified plan, CBS rights itself in about 6 months. Yasko sells a million things, so there are multiple ideas of how to treat CBS but here is one. I take Phosphytidal Serine and TMG right now and I dont have CBS.. Im just trying to jumpstart my known MTHFR defects by doing a shortcut over to SAM-e with TMG
___________________________________________

Glutamate is the main excitatory neurotransmitter in the body. It is essential for learning and short and long-term memory. Glutamate is also the precursor to our primary inhibitory or calming neurotransmitter, GABA. GABA damps the propagation of sounds so that a distinction can be made between the onset of sound and a background noise. Many other physiologic processes require a balance between glutamate and GABA, which is usually easy to achieve as glutamate, glutamine, alpha-ketoglutarate, and GABA can be interconverted via the enzymes depicted above.

Genomic defects, viral illness, and heavy metals will compromise this balance, leading to excess glutamate, insufficient GABA, excitotoxicity, and eventual neuron loss. Viral infection (individuals with Methyl Cycle defects cannot defend well against viral infection) can lead to antibodies against the vitamin B6 dependent enzyme glutamate decarboxylase (GAD), blocking GABA production (this is felt to occur in the pancreas in kids with juvenile onset diabetes). Aluminum poisons this enzyme as well. Excessive alpha-ketoglutarate generated due to the CBS up regulation can be converted into glutamate, but in the presence of lead and aluminum, the glutamate so created cannot be converted into GABA, glutamine, or back to alpha-ketoglutarate. The result is glutamate-GABA imbalance, agitated behavior, and eventually nerve loss.

Low GABA leads to impaired speech, anxiety, aggressive behavior, poor socialization, poor eye contact, nystagmus, and constipation. Glutamate excess does the same and also wastes glutathione and increases levels of TNF-alpha, an inflammatory mediator that can produce heart cell dysfunction and gut inflammation.

We can restore glutamate-GABA balance by:

1. Addressing CBS up regulation/BHMT down regulations to decrease alpha-ketoglutarate production.
BHMT converts homocysteine directly in to methionine. Specifically it removes a methyl group from TMG (trimethylglycine) and tacks it on to homocysteine to form methionine and DMG (dimethylglycine). Stimulating a genetically normal BHMT system will partially ameliorate the adverse affects of Methyl Cycle defects elsewhere. For example, if we cannot convert homocysteine in to methionine because a MTHFR defect renders us deficient in methyl-folate, or if an MTR up regulation or MTRR down regulation leaves us short in the methyl-B12 department, we can bypass these blockages by stimulating BHMT to convert homocysteine directly in to methionine (I know this is difficult, but bypassing blocked enzymes sure beats surgery to bypass blocked arteries, so please read on). Our approach to BHMT, if it is defective, or when we want to stimulate BHMT to help bypass MTR/MTRR defects, or when we want to pull homocysteine away from a CBS up regulation, will be affected by your COMT (basic need for and tolerance to methyl group donors) status. The basic approach is as follows:



1. Phosphatidylcholine, or as a less expensive alternative, Phosphatidylserine 100 mg daily, to stimulate the BHMT reaction. The former, administered IV as Lipostabile/Plaquex, or in oral liposomal format as Lipophos Forte, provides a powerful anti-atherosclerotic benefit (discussed on the website and in a DVD). Oral Lipophos EDTA contains Phosphatidylcholine admixed with EDTA, providing us with BHMT stimulation, reverse cholesterol transport, and heavy metal detoxification, a triple benefit. In individuals who are COMT (-/-), who thus need methyl groups, Phosphatidylserine can be used in combination with the methyl donor DMAE as Pedi-Activ, one daily.
2. TMG can be used to stimulate BHMT (but not in COMT (+/+) individuals, who will be sensitive to free methyl groups).

________________________________
2. Decreasing intake of food precursors of glutamate (see list below).
3. Supplementing with GABA
4. Copper inhibits conversion of glutamate to GABA by glutamate decarboxylase so avoid copper excess, or better stated, an imbalance between copper and zinc.
5. Calcium is involved in glutamate toxicity, so supplement with magnesium to keep calcium in check.

6. Remove heavy metals with a chelating agent. Of interest, toxicity due to mercury is aggravated by glutamate excess; mercury and glutamate synergize to damage nerve cells.



Sources of Excitotoxins – Short List*

Glutamate


Glutamic acid, glutamine, MSG, peas, tomatoes, parmesan cheese

Aspartate


Aspartame, Nutrasweet

Whey protein


Soy protein


Hydrolyzed anything


Cysteine

Malted barley


Malt extract


Natural flavoring(s)


Guar gum

Gelatin


Carrgeenan


Soy sauce


Bouillon

Vegetable gum


Broth/Stock


Yeast extract


Autolyzed anything

*Long list in the appendix

Treatment Options

Pycnogenol and grape seen extract help balance Glutamate/GABA

Taurine helps in this balance (but contains sulfur so avoid if CBS (+)

Montief GABA

ZEN
Contains threanine, which has methyl groups; avoid if COMT (+)

So I ordered the supps yesterday and they've just arrived! Do you think I should start one at a time or all together and should I expect and "detox" for the detox???

Oh cheers, I lost your email address and I'll respond to you from there so as not to bore others with these details!

What's the allergist say she is allergic to?

www.medscape.com/viewarticle/721700

Oh my word! This is SO interesting. Me and ALL of my eight children have histamine/salicylate intolerance and a few of them have awful behavioral issues, probably on the ADHD spectrum. And then my oldest has UC on top of it all. I read through all of this and will re-read through it all again.

I feel like PP mentioned, a little ticked that this has not been brought up before. But I understand everything starts out as new. How great there are these tests! I have been trying to navigate through myself for a couple years now.

Thanks so much!!!

ConquerUC, if something like olive leaf gave you leg and muscle aches you dont need to abandon the supplement you need to finish killing the pathogen that is dying off and giving you those symptoms. When people email me that is the hardest thing to communicate to people. When you have something like UC this is a chronic issue. If it is caused by a pathogen its going to cause die off. You HAVE to push through the die off. There is no easy way to come out the other side, herbs are more gentle then rxs.

Okay, now that I sound like broomhilda...

I think 23and me is plenty of info. I would not waste money on yasko.. there are many other tests Id use that money for.. CDSA, spectracell, Urine amino acids..pathogen testing.. in that order. For me,the roots of my issues are pathogens. BUT the reason why I am sick while others are not is epigenetics. That's what we all ask ourselves all the time, right.. why are we sick and other's are well as we eat super restrictive diets and try every remedy suggested. Well, when your methylation cycle or mitochondrial cycles are off your body cannot defend itself and beyond that sometimes it's so off kilter that it attacks things it shouldnt, like your own self..

For me, when I started supplementing for my defects what it did was, not fix everything.. but allow my body to do a couple things

1. detox.. over the years I never sweat, I never had acne, Ive had constipation the last several years as I played with herbs to kill things not knowing my detox was compromised so the toxicity of the kills just made me sicker Detoxing was key because once the bad stuff started being able to actually clear my body could identify what was friend and foe alot better and my whiteblood cells could attack the bad guys instead of just work on cleaning up all the mess and waste products. As the waste products cleared the environment for yeast and such was not as favorable.

2. The B vitamins allowed my body to have the reserves to start making the cells it needed, which was more white blood cells.. and increased mitochondrial energy. My body simply did not have the energy it needed to heal because my nutrients were not making it into the cells. Lots were being scavenged by the pathogens I have, and some where gunked up with nonbioavailable forms of folic acid.. or I didnt have the precursor enzymes needed to deliver the vitamins because my bacterial make up did not produce them.


So for you, conquer UC.. Id be curious as to what 23 and me says, then you can work on getting your paths moving and detox started.. and then, likely you need to hit any pathogens just hanging around.

While you wait since you do react to sulfites you can try eating a low thiol and sulfur diet as that is what Dr. Amy says is the first step, clearing the Cystahione Beta Synthase pathway.

Post Edited (PathogenKiller) : 8/3/2013 10:22:15 AM (GMT-6)

Yes yes, open your pathways first! Sorry I should have clarified that better.

But die off is still likely to suck.. not as much tho.


Ya know, I have no real opinion about the sulfur. Im just regurgitating the info I have from the folks that know way more then I do about methylation. Some people are really helped by restricting, some are not.. it does seem that across the board people who noticibly are reacting to sulfite/sulfur seem to feel better on the diet. The idea is that the Cystathione beta synthase pathway is upregulated in folks with CBS polymorphisms basically pulling all your detox ability down a drain and creating more sulfur instead of things like glutathione.