The vesicle-associated function of NOD2 as a link between Crohn’s disease and mycobacterial infection
www.ncbi.nlm.nih.gov/pmc/articles/PMC4316803/This goes along with the above in regards to MDP
What I found more interesting however was learning from the article that Mycbacteria lipids (fats etc produced by the bacteria) can exit the infected cell and in turn effect neighbouring and even nearby cells. So infection of one cell could lead to the same immune effects in a large number of cells even though they are not actually "infected" by the bacterium themselves.
More so, mycobacteria make an effector molecule called sulfolipid (SL-1) - So this (SL-1) mimics a lipid that we normally make (and regulate) as well. It is through this means (the production of SL-1) that mycobacteria can hijack the functioning of our immune system in their favour. What was interesting was the article suggests that this little process can perhaps trigger stem cells to develop into Enterochromaffin cells instead of other types and this in turn (the excessive amount of EC cells) are perhaps responsible for the increase in Serotonin found in patients with Crohn's. Same with IBS.
Professor Herman Taylor (The Crohn's Vaccine Guy) is convinced MAP is also responsible for IBS.
Anyway - tough read but lot's of intriguing things to think about
.
EDIT: Also the Serotonin thing and OCTN Gene defect part got me thinking about
the wild response to the Amino Acid Therapy.
Post Edited (Canada Mark) : 2/26/2015 7:33:41 PM (GMT-7)