Radical Induction Theory-Time to re-visit

Old Mike,

that is interesting. Not sure in my case. I was taking vitamin D in tablet form for ages. Maybe it's the ALA kicking in, but it also seems as if there's something about either the liquid Vit D or the additional Vit K that made the difference.

That said, the really annoying thing is my spinal arthritis continues to be quite bad. I'd hoped it was directly linked to my IBD, although my rheum and gastro both said that while the two are connected one can be bad while the other is quiet. Rheum also said unlike IBD the arthritis doesn't go into remission and my best hope is Humira (although another rheum I saw was of the opinion that it can and does go into remission if the IBD is well managed). I'd still hope the arthritis is linked to excess oxidative stresss, but it is it's not responding as well as my gut has to diet changes and supplements so I am not so sure. Leaky gut would be the other theory, but that ought to be healing given my reduced GI symptoms. Other than an even more restrictive diet, which I am less than thrilled by the idea of, I am sort of stumped on next steps to try for my back.

I guess even though I am in remission for IBD and only ever had a mild case, I am still looking at Humira as my best option. The fun never stops.

thanks for this--interesting. Am waiting for my order of sodium butyrate. I knew there was one supplement I was still missing.

I assume you've seen this site. Very useful summary of research to date...

http://examine.com/supplements/Alpha-Lipoic+Acid/

Not great, but then again as with so much in this area a lot of the research isn't big enough to meaningful either way.

Well, I'll be a son of a gun.

I started to go a little down the path of what works in UC in relation to peroxides/ROS.

As Spock, bless his soul, would say, fascinating.

Infliximab/Remicade.

I say, are you kidding me.

Old Mike

Cant seem to get this paper even an abstract, I wonder why,will keep looking.

Infliximab Modifies Circulating Reactive Oxygen Species and Restores Serum Antioxidant Potential in Inflammatory Bowel Disease Patients

more on peroxides and Infliximab

http://www.ncbi.nlm.nih.gov/pubmed/16114504

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065336/

http://www.clinexprheumatol.org/article.asp?a=3268

One the subject of FMT we UC people have a dysbiosis of facultative anaerobes way too many.

These are oxygen loving, the colon should lack oxygen.

Where does all the oxygen come from, you guessed it ROS/peroxides/iNOS ect.

FMT replaces all of these with strict anaerobes that should be there.

You can see some of the mechanisms that go on in the two papers below.

There is a lot of cross talk and feed back, between the bacteria and immune system.

I can guess why it does not work in some, due to excess ROS wiping them out again,or they just do not take.

The two cases below did not have IBD but we can see what is going on.

The question is can we revert the gut bugs by lowering ROS without FMT.

From Pravdas human trials, I might guess you can.

got to through in the dysbiosis oxygen hypothesis again for IBD

http://www.nature.com/ismej/journal/v7/n7/full/ismej201380a.html

on a different subject here is what goes on with FMT and C diff

http://www.microbiomejournal.com/content/2/1/13

on another subject what goes on with FMT and sepsis

I might suspect what went on here is pretty much what goes on with the gut bacteria for UC FMT

http://www.omicsgroup.com/conferences/ACS/conference/pdfs/16568-Speaker-Pdf-T.pdf

notice the ones we are missing in UC are strict extremophile anaerobes

Clostridium cluster XIVa and IV

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751348/

on another tangent, dietary iron and ROS will look at it more from the aspect of UC

food fortification again comes to mind as a problem

http://www.ncbi.nlm.nih.gov/pubmed/22414964

phytic acid iron ros

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1727824/pdf/v046p00225.pdf

more phytic acid

http://heal-thyself.ning.com/profiles/blogs/controversial-phytic-acid

 

OM, I believe I've asked you before, have you researched gastrointestinal endocannabinoid system and its relation to cannabis' anti inflammatory effects? Cannabis reduces intestinal inflammation MASSIVELY. It doesn't just slow the motility like opiates. Maybe you can find some links with radical induction theory...

I actually have the same belief and experiences with probiotics, bacteria... Maybe it is best to avoid prebiotics. Potato starch has huge potency to increase microorganisms in the gut. I should think about it more and most probably be more cautious...

CM, I'm still flaring. Will start antibiotics in 2 days. Did you take probiotics while you were on IV antibiotics?

I saw you in crohnsforum.com. Very informative forum.

Just read that study on the custom enema, I think think that stuff could help a lot of people. Presumably, it's working to take the burden of detoxification away from the body so it can focus on healing and restoring the mucous membrane in the colon. Functional medicine - allowing the body to heal itself - at its best. Personally, I've never subscribed to the autoimmune disease myth for anyone's condition. I really hope he gets the money he needs to continue his research.

That's two of us then, do we need one more for a crusade?

Xy123, thanks for that tip. What type of arthritis did you have? And do you still eat other proteins (beef, lamb, duck, soy). The arthritis is much more upsetting than my UC and while I am slowly coming around to the prospect of Humira, still would prefer to avoid it.

Oral:

• ALA
  

Enema:

• mesalamine
  
• budesonide
  
• cromolyn sodium
  
• sodium butyrate
  

I have been taking ALA and mesalamine for weeks.

How much ALA should we be taking ?

An update from me:

Things have been slowly but surely getting better. I'm having more solidified stools and times where I'm having liquid stools are slowly becoming a thing of the past. Some days my uveitis is basically gone, and some days it comes back, i'm not quite sure why it is doing that, but all other signs are good so far.

I think budesonide and cromolyn may be two aspects of Pravda's treatment that might be responsible for how quickly people responded to it and got better. Tight junction repair is critical to maintenance of the barrier, and downregulating cytokines and other inflammatory things will allow the colon to heal faster. Without these things, healing is going good, but pretty slow and I'm thinking that the left colon which has undergone the most damage for the longest probably has a more compromised barrier that leaves me prone to a higher level of inflammation w/ increased protein. I'm still noticing improvements, so it's likely that the barrier is getting better, but slowly. The more solid/less cloudy stools and improvements in frequency and function are likely indicative that things are getting better overall.

One thing - i think ALA is definitely contributing to sudden hair loss for me. As well as an increased amount of gray hairs. Apparently biotin supplementation will ameliorate this, so gonna pick some up and see how I do. So something to look out for if you're taking ALA.

Also began to take rectal mesalamine, will probably end up putting butyrate in the enema as well. Thinking my left colon/sigmoid area isn't getting enough help. So far so good, it's only been a few days.

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Also in response to your biofilm thread OM, you said you didn't know how to make the mucus membrane better... well that's a central aspect of RIT, is it not? Peroxides damage the structures critical to maintenance of the mucus barrier. Remove the peroxides, inflammatory molecules, give the colon energy, support antioxidant function and decrease peroxide formation and theoretically the structures responsible for a good mucus barrier will heal. In the other biofilm thread, it said healthy humans don't have biofilm formation in their colons because the colon is constantly replenishing its mucus creating a sort of movement that doesn't allow for biofilms to settle.

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Anyway, i'm just gonna keep doing what seems to be working. Hope you all are doing well.

@xyz - no, I stayed away from probiotics while on IV antibiotics. Actually I sort of stayed away after as well except for a very small amount that is already in a type of meal replacement that I used to put weight back on ~1 billion per serving - Bacillus coagulans GBI-30. And I also took L.reuteri in small amount as well (liquid form from BioGia). Both seem to do very well with my system. Both servings were a billion or less per day. I stopped the reuteri after a week. My stool was well back to normal before then - and actually far better than before.

It's actually kind of funny, but since the IV antibiotic ordeal I seem to actually have far to much perfectly solid stool now... never thought I would say that.

My crazy cat takes these giant craps and runs around the house like a mad man after.... I used to be jealous of the size of his poop. Was bigger than mine! (and most peoples) And huge for a cat. Seriously, it's unreal. Now I can say I understand why he runs around after....

I've been taking 300 a day. Not sure if it's helping. Sometimes I think it is but improvement hasn't been linear or swift.