Read this this morning and thought I'd post the link for others who may be interested as many studies have wondered how tolerance was established. Will be interesting to see some follow up studies on this.
Investigators show how immune cells are 'educated' not to attack beneficial bacteria
medicalxpress.com/news/2015-04-immune-cells-beneficial-bacteria.html------------
I have to say though, I don't quite agree, nor disagree with the authors write up - but to me, personally, I believe this is one of the more important papers supporting the role of MAP in Crohn's disease.
Both good old plain jane tuberculosis and MAP (Mycobacterium Avium Subspecies Paratuberculosis) contain and even secrete certain proteins that specifically inhibit our antigen presenting cells to both process and present MHC-II antigens. 'Tolerance' according the the above paper is established through MCH-II presenting between immune cells. T-cells now being shown as 'educated' or more so "eliminated" on the gut side as ILC's destroy the T-cells that target our friendly's. Since MAP directly interferes with this process, likely this would lead to inappropriate response to normal bacteria as the T-cells that are targeting our friendlies and perhaps even certain foods are no longer being 'educated' or eliminated.
So the adaptive arm of the immune system 'tolerance' goes all wonky. This is why Professor Hermon-Taylor says that persistent MAP infection causes the underlying problems - i.e leaky barrier, strange all over the map food intolerances etc etc.
So to me it was a highly interesting article on both fronts - the MAP side of things and the immune system operation side of things.
Post Edited (Canada Mark) : 4/25/2015 7:22:17 PM (GMT-6)