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Antibiotic Therapy Help Please

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Ulcerative Colitis
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Posted 11/18/2015 1:53 AM (GMT -5)
Normally when I get in a bleeding flare the antibiotic Metronidazole ( Flagyl) controls symptoms almost immediately along with an increase of Mesalazine to max dose.

I took it in July and although it lessened symptoms it didn't completely get rid of the bleeding this time. I took 400mg 3 times a day for a week.

I'm now taking enemas, suppositories and Pentasa and was thinking about adding the antibiotic again to really push it hard.

What are your experiences on antibiotics?
Can I try them again after only 4 months?
And are there better ones than Metronidazole for IBD?

Thanks
LR
Posted 11/18/2015 3:52 AM (GMT -5)
I have only taken metronidazole for an unrelated problem (cartilage infection). It was like a magic pill for my IBD and made me feel better than I ever felt ... Talked to my GI about use for my IBD. Whilst I had no option to take for the other problem (for many months) he refused to prescribe for IBD. He indicated it was not a suitable treatment and went through the major long term side effects of prolonged or repeated use. Never had since.
Posted 11/18/2015 5:15 AM (GMT -5)
Well it is definitely used for IBD across the world (you can Google it and see), especially for initial flare up - I am wondering if I can take it again after only taking it 4 months ago.
Posted 11/18/2015 6:15 AM (GMT -5)
Tbf I do know it's widely used - I was just giving you my experience. Whilst I don't have a view about this drug, wide usage isn't necessarily a good thing ... Look at pred. Widely used but certainly no ones drug of choice. In my case the GI I saw at the time would not (and indeed no GIs before or since) prescribe this as a maintenance drug.
Posted 11/18/2015 6:50 AM (GMT -5)
I am talking about maintenance, but about when in a flare only.
Posted 11/18/2015 7:41 AM (GMT -5)
Interesting discussion about flagil in this thread. Apparently it is useful for getting out of a flare but dangerous for maintenance. It kills both good and bad bacteria, some can get C Diff from overexposure. So once in remission take probiotics for maintenance and to replenish your good bacteria.

https://www.healingwell.com/community/default.aspx?f=38&m=3485660

Post Edited (Coffeemate) : 11/18/2015 5:52:06 AM (GMT-7)

Posted 11/18/2015 9:56 AM (GMT -5)
I am going to stay on high dose 5ASA for 2 more weeks and then try Flagyl again for a week. I will take VSL3 every day in double doses for the time I am on it.
Posted 11/18/2015 11:02 AM (GMT -5)
S. Boulardii is also good if you can tolerate it. It is not a bacteria but a probiotic yeast not killed by flagil and proven to resist C Diff.
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