WorriedUCer said...
H
Marauder93 said...
Biologics =/= immune system targets. They are just drugs made my living cells. Eg. Insulin is a biologic. But all of our drugs target the immune system. Considering this disease is a result of a dysfunctional immune system, how do you plan on fixing it without targeting it?
I actually disagree fundamentally with the point that "this disease is a result of a dysfunctional immune system". Just because our immune system is activated does not mean that it is dysfunctional. Given the fact that the less than 5% of our bacterial microbiota is able to be cultured, and don't even get me started on the virome, that is a gigantic amount of dark matter living within us (no pun intended). Stomach ulcers were once thought to be a stress response by our bodies until they found the cause, helicobacter pylori infection. I personally don't believe the solution is tinkering with our immune system.
I also disagree with the comparison to insulin which is a well known hormone with a fairly narrow metabolic pathway. The same most definitely cannot be said for IBD biologics. Progressive multifocal leukoencelopathy is one such example. Tuberculosis is another. Insulin does not have this side effect profile.There is certainly more going on than JUST a dysfunctional immune system (such as the things you mentioned), but you cant deny that without fixing the immune system as well, the disease will never be fixed. There are observable and documented dysfunctions that are only present in autoimmune diseases and IBD. To say they dont exist or that they can be ignored is just factually incorrect. A healthy immune system does not attack a microbiome or virome.
And the comparison to insulin was to explain that biologics =/= immune system targets as you suggested. I NEVER implied that that biologics we take are somehow safer than insulin... not sure how you interpreted it that way.