Currently in a flare, what to do next (entyvio and other drugs)

lauraalaur

New Member

Joined : Apr 2016

Posts : 1

Posted 4/28/2016 3:12 AM (GMT -5)

I have had uc for a little over 10 years now. Before this past year, I was relatively healthy, never had a lot of flare ups and always managed them through switching meds or adjusting something with my meds. I had a lot of success with remicade, I was able to take it for 5 years before I built up antibodies and had to switch this past summer. I started Humira shortly after but after 8 months of being on Humira, I had the worst flare-up of my life at the end of February and have been in constant pain, had diarrhea, and have been unable to eat because of my discomfort and nausea since then. I'm seeing my doctor again soon after prednisone failed to help my flare and was wondering what medications people started using after remicade and humira? I am currently taking lialda, methotrexate injections, omezaprazole, folic acid to control my uc (I stopped Humira a 2-3 weeks ago because my doctor and I agreed it wasn't working). I am looking into entyvio as a possible next step.

Also it's been a nightmare managing this past flare since I go to school 16+ hours away from home and have to see a doctor who consults with my GI doctor from home to figure everything out.

Happier!

Regular Member

Joined : Feb 2014

Posts : 328

Posted 4/28/2016 5:17 AM (GMT -5)

I have no answers. Just offering sympathy.

Perhaps your body is telling you that you are doing too much?
I believe that may be what triggered me.
I had to just slow down. Sleep. Walk the dogs. Take time. Delegate. Lower expectations. Say no. And sleep. And sleep.

iPoop

Forum Moderator

Joined : Aug 2012

Posts : 16495

Posted 4/28/2016 6:25 AM (GMT -5)

There's several more biologics approved for uc. Simponi is another biologic similar to remicade and humira. Entyvio is a different class of biologics.

There's a few more approved for RA, now undergoing clinical trials for uc: Stelera and Xeljanz

janey47

Veteran Member

Joined : Sep 2010

Posts : 765

Posted 4/28/2016 6:30 PM (GMT -5)

I learned recently that my cousin, who has intractable Crohn's, was in one of the clinical trials for Entyvio and, counting that time, she's been on Entyvio for more than 3 years and it is working well for her.

DBwithUC

Veteran Member

Joined : Feb 2011

Posts : 4545

Posted 4/28/2016 6:58 PM (GMT -5)

this sounds a lot like a c-diff infection. did they check?

Charlie3

Regular Member

Joined : May 2013

Posts : 293

Posted 4/29/2016 9:06 AM (GMT -5)

Entyvio is the only drug that worked for me
I have had UC for 4 years now , failed all other drugs

TroubledTurds

Veteran Member

Joined : Jan 2004

Posts : 8722

Posted 4/29/2016 9:44 AM (GMT -5)

i agree with DB -

ks1905

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Joined : Sep 2005

Posts : 6438

Posted 4/29/2016 9:50 AM (GMT -5)

Anytime that you flare you should do stool cultures just to rule things out. I ended up with c.diff while I was on Humira.

I'd move to Entyvio because you have antibodies to Remicade. Once I developed Antibodies to Remicade then none of the other anti-tnf biologicals worked for me. I tried Humira, Simponi and Cimzia.

Have you tried 6-mp or imuran?

therearemiracles

Veteran Member

Joined : Dec 2006

Posts : 3839

Posted 4/29/2016 10:07 AM (GMT -5)

If remicDe helped maybe entry it will too. No biological helped. Antibiotics s help me the most with asacol hd

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