Posted 9/27/2018 8:06 AM (GMT -5)
I'd say the answer is it depends, and there's no guarantees.
First, when we have a lot of inflammation within our intestine, there's bodywide collateral as a consequence thereof. That over aggressive immune system may target other things beyond our large intestine as extra-intestinal-manifestations of our UC (causing arthritis, eye inflammation, sinus inflammation, rashes, etc., etc.). We have WBCs (the immune system's attack dog) and others circulating the whole body within our blood. Often when we're flaring, our arthritis and muscle pains are at their worst (talk about a double-whammy). Often when we're in a remission, our muscle pains and arthritis pains are gone completely. That's suggestive of such collateral damage, that when the immune system is in a quiet/quiescent state, that our other issues are gone. If that's you, then I'd say there's a good chance that surgery would help relieve you of those pains.
Second there's joint and muscle pains that are unconnected with the state of our UC flare/remission cycle, and does not share the above mentioned pattern at all. We can have really bad pains while our UC is in a remission, as an example. If that is your case then a surgery may not relieve you at all from those pains. It's something else going on that is unrelated to your UC activity and body inflammation.
If you did want to pursue other UC medications, you've only tried the tnf-alpha-blocking class of UC biologics (humira and inflectra/remicade). There's entyvio (madcam1-blocker), there's xeljanz (jak inhibitor), which have completely different mechanisms of action and a chance at helping.