Hi all,

I've been back on pred 40mg for the past 6 days as symptoms started to come back when tapering. I'm having some improvement, bleeding has decreased but am still having bad urgency in the morning and feel like I'm straining to go... Is this a sign of rectal inflammation? I'm not really sure what is going on?

Ditto the above. Yes signs of rectal inflammation. Your flare sounds like it has gotten worse (unless you suddenly got c diff which is possible).

1.) You could ask for a stool test for infectious-causes as no response from 40mgs of pred makes you wonder if there is an infection (which would get worse with more pred).

2.) If it is an exacerbation of your flare then biologics sooner might be the best plan (although you might ask for endoscopy to prove the need if you are unsure what's going on up there).

3.) Also possible to give the 40mgs of pred more time, it might kick in within another week.

Not always clear and simple answers. Some times you run a bunch of labwork (test stool for infections, and get endoscopy) and see where you are at. Just make sure to keep in contaact with your gasteroenteroligist's office, to check in regularly in regards to your symptoms and progress (or lack thereof). Plans can change dynamically for you based on where you are at, and how you're doing with your doctor's assistance.

My son struggles with mild rectal inflammation but I must admit i would try as some of the experienced members suggest with regards to the rectal meds.

They work in our case very well, not sure why some seem hesitant to try them, it’s certainly worth a go.

Give it a shot.