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Root cause of the UC

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Ulcerative Colitis
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Posted 5/26/2019 9:42 AM (GMT -5)
Nowadays and before this time i was thinking a lot about what can be the real root cause of the UC.
Ok i know that it sounds stupid that i can relaize what is the cause of this illness, and there are lot of doctor and resarcher who can not find the root cause and why me could find the root cause.
Ok i can not find but i can have theory....

i think we are a little bit better position than the doctors to understund our body, our symptoms. And we live together with this ilness long time ago.

So in tgis way maybe we coould determine maybe what can be the cause,
....
It sounds stupid, but i belive that we can help to the doctors with our invidual ideas to find the right medicines and so on...

I hope u understand me (because my poor english)

So i read a lot of in this topic...i read every new articles every new medicine and usualy my knowledge is up to date.

So novadays i am thinking about maybe it cause a bacterium or virus or parasite and our immunsytem give an answer for this problem.
And not the immunsystem give a wrong answer and attack my body but immunsystem attack the bacteria or virus.
And a virus attack our bowel because our immune system is too weak( because of the big stress or antibioticum killed most of the usefull bacteria and so on)
So the immune system can not give the strong enough response for the attack which come from bacteria or parasite and make inflamination in our bowel. Because our immune system is too weak...

So maybe this is the root cause.
I Think it because of more things...
I eat lopedium (immodium) its effect is very very good for me and can recover me if i have bad days.

Why?
Maybe because as i know it kill the bad bacterial?

The antibiotiotics medicines can not kill every parasites, and viruses and the other which can make inflamitaion.
And there are lot of expereriences which say that antioxidant pill and meals could help regarding the decreasing of the symptoms.

So...maybe it cause bacterial viruses or similar things?

And we should focus for the taking lots antioxidant thing because our immunesystem is too weak because of some causes....(stress, antiobiotics and wrong meals and wrong eating killed our usefull bacterium in our bowel therefore our immunesystem can not work in normal way)
Therefore parasite or bacterials can inflame our bowel...

Opinons? smile
Posted 5/26/2019 11:41 AM (GMT -5)
There is a lot of research on the collection of bacteria, viruses, fungi etc living in our intestines at the moment so if this is true I think it will be discovered soon. There have been some recent discoveries of various "biofilms" which are slimy collections of fungi and bacteria that work together in the intestines of people with IBD.

I think it is hard for researchers to figure out whether something is the cause of IBD or if the IBD causes certain bacteria/fungi to take hold.
Posted 5/26/2019 12:41 PM (GMT -5)
I'm always hoping they will identify a pathogenic origin for uc (virus, bacteria, whatever) then all the friends/family around me who think I'm doing this with the power of my mind can stfu.
Posted 5/26/2019 1:14 PM (GMT -5)
I was diagnosed June 6th 2018 with ulcerative colitis ... was then told October 2018 that one of my ultra sounds detected endometriosis and a cyst ... the cyst has resolved itself and i am now post menopausal so no more endometriosis... but with the ive done on my own i found medicine net and mayo clinic and webmd have linked UC & CROHNS are linked to endometriosis being ignored or not diagnosed ... the only way to confirm or rule out endometriosis is to do a procedure ... all the symptoms i told doctors bout starting 15 years ago i found everyone when i googled endometriosis last year ... my gynocologist it seems has done this to me and come hell or high water i will make sure she doesnt do this to anyone else ... and i fired her last october too since she said with your recent diagnosis she wasnt comfortable doin the procedure on me ... funny that its a strong probability its cuz of her ignorance and neglect BUT ... four other gynos have said they wont do that procedure ... doctors try to protect each other ive discovered ...

I almost died from dehydration and malnutrition this past december from extreme diarrhea from 2.2018 to 12.2018 ... was hospitalized for a week and my work has also caused me stress with screwin me out of my short term disability with my supervisor on my butt everyday saying tina its only suppose to be such and such ... cept the fmla people told me to ignore them cuz we would just fix the days out allowed ... so they did fix that then i had a new supervisor telling me we need to get a bathroom note to metlife so we know its a valid reason ... as if being hospitalized and put on an fmla and now it says 4 flares a month each lasting 7 days is not valid ... my work has caused undo stress which is a HUGE trigger for flares .. im not controlled yet and not near remission yet either and I am still searching for a gyno to do that procedure to confirm endo damage or rule it out ... i am hopeful to be in remission soon ... but my GI doc says my case is very extreme ... i am taking lialda and Humira .. both for UC and i am still not controlled yet ... had to stop the steroid as it was raising my sugar a1c and they wanted to put me on yet another pill ... told them no i aint takin a pill cuz of another pill thats stupid and i dont do stupid ... i am goin to be an advocate for both UC and ENDOMETRIOSIS ... DOCTORS AND NURSES NEED TO LISTEN TO THE PATIENT ... my gyno i fired last year all she did with the symptoms i told her bout was put in an IUD .... then it fell and she had to remove it and when she did that if i had been a cat i woulda been stuck to the ceiling because it hurt taking it out ... an 80k dollar book doesnt mean you doctors are god or know it all ... LISTEN TO THE PATIENT EVERYTIME AND STOP TRYING TO SEE TO MANY EVERY DAY ... THAT IS WHERE WE GET CRAPPY CARE ... we arent horses housed in kennels .... and poopydoop if your family thinks that stay away from them if u have too ... and if ya can ... the stress isnt good for ya ... ya need people around who are gonna be there for ya and not hinder your recovery
Posted 5/26/2019 1:34 PM (GMT -5)
If you rethink the whole process and what we are doing and how try we cure this illnes then you can see there are lots of equipment medicines which alude to it can cause some kind of bacteria or parasite or something else.

We take d vitamin to make our immune system stronger, we take probiotixs to make healthier gut bacterium balances..
But aloe vera is very good antioxidant lots of person drink it according lots of report this is usefull.
And so on...

Only one think i dont understant ...rhis kind of biology therapy ...which block tnf.
Normaly as i know it makes our immune system weaker...

So why does it work ?
Maybe my theory (that it can any bacterial, virus...etc) Is wrong bevause of this....
Posted 5/26/2019 1:44 PM (GMT -5)
I think the biologics turn off your immune system so that your body will (hopefully) stop attacking itself ) ie the colon.
Posted 5/26/2019 5:08 PM (GMT -5)
That's why I donated part of my colon for research so I hope they find something and help future generations.
Posted 5/26/2019 6:59 PM (GMT -5)
These ideas need to be folded into knowledge about the gut microbiome, and its symbiosis with the host immune system. These ideas also need ot be combined with frameworks like triggering events. Also the vast knowledge about genetic involvement and the complicated signaling in the immune system needs to be taken into acount.

With the exception of MAP for CD, there is very little credible evidence fo an ongoing pathogen driving UC. Most such thinking is overly simplistic. I think the discovery of pathogens associated with stomach ulcers has set UC patients back decades because many blindly insist it has to be a pathogen, and if eliminated there would be a cure. This is a kind of denial. Too many other facts are known that do not fit such a simple model.
Posted 5/27/2019 8:18 AM (GMT -5)
It's possible that IBD is caused by a parasitic virus or bacteria. In cattle a bacterium called Mycobacterium paratuberculosis can cause an illness called Johne's disease - a wasting, diarrhoeal condition very similar to Crohn's disease in humans. There is a lot of ongoing research but it is still unclear if this or similar bacterium could trigger intestinal inflammation in humans.

Hambo88 said...
Only one think i dont understant ...rhis kind of biology therapy ...which block tnf.
Normaly as i know it makes our immune system weaker...
So why does it work ?

Yes immunosupressants help with IBD, but they are also effective to curb inflammation in meningitis, tuberculosis, and leprosy which clearly are infectious diseases.
Posted 5/27/2019 9:42 AM (GMT -5)
Could be autoimmune (with genetic predisposition/ weakness) or infectious with same genetic weakness). Who knows?
Posted 6/6/2019 1:50 AM (GMT -5)
My learned view is that even though we all have the diagnosis of UC, it may have a different cause in each of us. In traditional medical systems like ayurveda and TCM, no two patients are alike. What modern medicine calls a single disease may have different root causes. What I know for sure is that genetics is the most lame of all the explanations, and it's what modern medicine blames everything on when they can't admit that they don't know something.

In my case, my UC was caused by subclinical ischemia to my mesentery, due to scholiosis and poor posture compressing my abnormal circulation. When the blood flow was restored, my flare stopped within a week I entered remission a couple months later.

Think about your skin... it can become inflamed from: a cut, a burn, a bug bite, a chemical, poor circulation, an allergic reaction, a genetic problem, a parasite, etc. Yet we would call it one thing: skin inflammation. The same is true of the colon. It's up to you to figure out what's causing your inflammation. Doctors won't do it for you. They can barely figure out one reason for UC let alone the possibly many reasons.
Posted 6/6/2019 2:21 AM (GMT -5)
And there's the trifecta!

How in the world do you *know* that your UC was caused by 'subclinical ischemia?' That sounds like something a naturopath or chiropractor would say, with no evidence whatsoever. But hey, it sounds scientific!

As for the genetics, they clearly play a role but aren't determinant. Modern medicine knows that and admits that.
Posted 6/6/2019 3:25 AM (GMT -5)

beave said...
And there's the trifecta!

How in the world do you *know* that your UC was caused by 'subclinical ischemia?' That sounds like something a naturopath or chiropractor would say, with no evidence whatsoever. But hey, it sounds scientific!

As for the genetics, they clearly play a role but aren't determinant. Modern medicine knows that and admits that.

The answer is: none of your business.

The story of my disease and recovery are not up for debate. Got it?
Posted 6/6/2019 4:17 AM (GMT -5)
You put them up for debate as soon as you make claims on a public forum.
Posted 6/6/2019 7:08 AM (GMT -5)
A 'learned view' that isn't up for debate! That's an oxy moron. smile
Posted 6/6/2019 9:59 AM (GMT -5)

poopydoop said...
I'm always hoping they will identify a pathogenic origin for uc (virus, bacteria, whatever) then all the friends/family around me who think I'm doing this with the power of my mind can stfu.

Hahaha! I, too, hope they find a pathogenic origin. It would just make more "sense" to me, and I like for things to make sense.
Posted 6/6/2019 10:13 AM (GMT -5)
My opinion is UC is pathogenic, and applies to those of us born with a genetic-weakness (or predisposition) and have the right environmental (food contamination like salmonella, repeat antibiotics, or any number of similar things) triggers/exposures. We're born with both active DNA and inactive DNA. Throughout our lives, Epigenetic-changes occur which activate formerly dormant DNA. Once activated, it changes how our body reacts and acts. So, if some really nasty DNA was activated that controls a more aggressive immune response, well you see where I am going here with autoimmune responses and endless attack on self.

Pretty sure on the epigenetic/environment stuff. As twin studies have shown that there is more than just DNA at play as identical twins often have just one with UC, not both. So there's some environmental triggers and epigenetic changes going on.
Posted 6/6/2019 3:02 PM (GMT -5)

beave said...
You put them up for debate as soon as you make claims on a public forum.

I was stating an opinion, not a fact.

Stop being so hostile, please.
Posted 6/6/2019 3:11 PM (GMT -5)
Just hit the ignore button. I must have that user on ignore because I can only see his posts when you quote them -- lol.
Posted 6/6/2019 3:36 PM (GMT -5)
Ditto. That's what ignore is for. I see some disagreement between you both, and that's the better option.
Posted 6/6/2019 4:39 PM (GMT -5)
I have no problem with disagreement but he is hounding me with unfounded accusations, such as me being a conspiracy theorist... and following me to every thread I post in to respond with rebuttals. I'm not here to argue with people.
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