Failing Humira

Hello all,

Week 9 of Humira with almost no real improvement, still urgency / frequency. Blood and D had stopped until step down from 20 to 10 of pred, then blood returned, no D though..... (rapid taper on advice of endocrinologist as now developed Cushing's).

Understand can take up to 12 weeks to see improvement, but we are at 9 here.....barring a miracle.

Do have some good days, but most are still typical flare days, some (like today!) just all day like a clean out day. Cannot leave the house. Lots of cramping and almost constipated (different than usual tenesmus. Heading in for first blood work / antibody check / next week.

What's been people's experience (WE ARE ALL DIFFFERENT AND RESPOND DIFFERENTLY), but have most of you - failing one biologic - tried another like Remicade or Entyvio?

Was so hopeful but really no meaningful change here.

Thx and stay safe!
P

I would give it more time, if I remember correctly you had some lag time before getting it approved. I know you said on the 8th you were doing some better, maybe you dropped the prednisone too fast. Are you on any rectal meds? I would see what the labs show, another option is to do weekly injections, this is not uncommon. It can be a bit of a hassle with insurance, but if the drs office staff is good they can get it done. I feel for you, when we feel bad one week can feel like forever!

Take care.

I failed Humira but had success with Remicade. I did have a response with Humira for awhile but not long . I guess I lost response but didn’t fail it altogether. I wouldn’t waste a lot of time with it if you’d had no response . You could try Remicade or a drug with a different mechanism.