COVID-19 INFECTIONS IN VACCINATED PATIENTS WITH INFLAMMATORY BOWEL DISEASE: OUTCOMES AND RISK FACTORS FOR SEVERE DISEASE
Emily Spiera, Danielle Ganjian, Xian Zhang,
Erica Brenner, Manasi Agrawal,
Jean-Frederic Colombel, Michael Kappelman,
Asher Kornbluth, Ryan Ungaro
BACKGROUND: There are limited data on coronavirus disease 2019 (COVID-19) in vaccinated patients with inflammatory
bowel disease (IBD). We aimed to describe outcomes and identify risk factors for hospitalization, severe COVID-19,
and death in this population. METHODS: Data from the Surveillance Epidemiology of Coronavirus Under Research
Exclusion in Inflammatory Bowel Disease (SECURE-IBD) database were analyzed. Patients with IBD who received at least one vaccine dose prior to diagnosis of COVID-19 were included. Patients received mRNA (Pfizer and Moderna),
adenovirus vector (CanSino, AstraZeneca, Sputnik, and Janssen), or inactivated SARS-CoV-2 (Sinovac) vaccines. Partial vaccination was defined as having not received the full complement of doses for the vaccine received. Outcomes were hospitalization, death, and severe COVID-19, a composite of intensive care unit admission, mechanical ventilation, and/or death. RESULTS: Among 141 cases, 12 (8.5%)
were hospitalized, 4 (2.8%) had severe COVID-19, and 1 (0.7%) died. During the same period, proportions in the unvaccinated were 9.3%, 1.9%, and 1.2%, respectively. Nearly three-quarters of patients with COVID-19 after vaccination were on biologics and one-third were taking
immunomodulators. Fewer hospitalizations occurred in those with completed vaccine series than partially complete series (5.7% vs 13.2%, p ¼ 0.13), and in those receiving mRNA vaccines than adenovirus vector (4.7% vs 22.7%, p ¼ 0.01) or inactivated SARS-CoV-2 (4.7% vs 16.7%, p¼0.15)
vaccines. Only 2.9% of those with completed mRNA series were hospitalized. Patients on biologic monotherapy were less frequently hospitalized than patients on immunomodulator monotherapy (4.2% vs 27.3%, p¼0.03) or combination therapy (4.2% vs 10.0%, p ¼ 0.36). Overall, hospitalized patients were older (mean age 50 years vs 40 years, p ¼ 0.03). Severe COVID-19 was less common in those receiving mRNA vaccines than adenovirus vector (0.9% vs 4.6%; p ¼ 0.31) or inactivated SARS-CoV-2 (0.9% vs 16.7%; p ¼ 0.02) vaccines. Of the four patients with severe COVID-19, two were taking tumor necrosis factor antagonists, three were taking azathioprine, and one had chronic lung disease. The only death was in a patient on triple immunosuppression with adalimumab, azathioprine, and systemic steroids. CONCLUSION: In patients with IBD, incomplete vaccination, non-mRNA vaccines, and immunomodulator use are associated with increased risk of adverse events during COVID-19 infections.
Sources:
https://www.gastrojournal.org/article/s0016-5085(21)04030-0/pdfhttps://www.news-medical.net/amp/news/20220121/hospitalization-risk-high-for-ibd-patients-with-incomplete-covid-19-vaccinations.aspx