Zymfentra

CCinPA

Veteran Member

Joined : Dec 2014

Posts : 2928

Posted 1/3/2025 1:00 AM (GMT -5)

https://www.zymfentra.com/patient-uc/

I just saw a commercial about this. It's a self injection infliximab. Anyone on this? Hard to believe that a self injection can take the place of a 2 hour infusion.

beave

Veteran Member

Joined : Mar 2007

Posts : 2496

Posted 1/3/2025 12:30 AM (GMT -5)

Yep, self injection of infliximab (or a Remicade biosimilar) and self injection of Entyvio have just recently gotten approval.

You have to do the injections every two weeks (I think), not every 8 weeks like the infusions.

They don't know whether this method of delivery is better, worse, or the same effectiveness. The trials proved that it works, but they haven't done head-to-head trials of the injections vs infusions to see which is superior or if they're about the same.

GrittyHope

Regular Member

Joined : Mar 2022

Posts : 146

Posted 1/3/2025 12:11 PM (GMT -5)

I love the idea of an injection for convenience, but the Entyvio Facebook group I’m in has too many reports of lost remission after folks shifted to the injection (it’s been approved in some places for longer than others). I know it’s risky to make decisions based on anecdotal evidence, but I’m keen to stay on infusions until we have more good data on the comparable effectiveness.

CCinPA

Veteran Member

Joined : Dec 2014

Posts : 2928

Posted 1/3/2025 8:47 PM (GMT -5)

It sounds like they are trying to turn Remicade into Humira. If 1 pen every 2 weeks if supposed to be the same as 5mg/kg every 8 weeks then I would need 2 shots every week using that same equivalency.

I am doing well and no desire to rock the boat so I will stay on infusions.

Seems weird that Remicade is weight based and Tremfya will be the same dose regardless of weight (like Humira).

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