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Does eating after taking a ppi make differance???

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GERD & Acid Reflux
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Posted 11/25/2011 7:40 PM (GMT -5)
Can any one tell me if eating after taking a ppi makes a difference??? My GP just told me to take them in the morning, he never mentioned food at all.



Cheers
Loz
x
Posted 11/25/2011 8:50 PM (GMT -5)
Loz-

I am told to wait at least 30 minutes before eating or waiting an hour after eating to take them.

Take care,
Bill
Posted 11/26/2011 6:27 AM (GMT -5)
There should be a paper that comes with your medicine that explains the effect of taking the drug postprandial (after food) or while fasting (before food), plasma concentration vs time.

for my medicine (pariet), if one takes before food, the onset of effect is faster, it reaches peak faster, and the effect gradually wears off. if one takes after food, the onset is slower, reaches peak slower (by a few hours), but it wears off with a higher plasma concentration.

for me, my reflux occurs mostly at night, I should be taking it after dinner, but the doctor doesn't know the difference, so i am stuck with taking it before dinner.

talk to your doctor about the difference, before you start.
Posted 11/26/2011 9:48 AM (GMT -5)
PPIs don't work right if you don't eat, but eating has to be about half an hour after taking the med - as Bill said. The acid producing cells are not affected if they are not turned on, which is why you have to eat - to turn them on. You just have to wait to eat until the med gets absorbed into the blood stream, as it doesn't work directly on the cells in the stomach but through the blood getting to the cells.

WJF - how about taking it in the early evening before a small snack? Still, don't lie down for at least a couple of hours. Or maybe you need to take it twice a day.


PPIs don't last 24 hours, no matter the advertizing. You can look up "duration of action" and the specific med (any med) on the 'net.
Posted 11/26/2011 11:42 AM (GMT -5)
I did a bit of research today on eating the right foods with ppi's, apparently the first meal should be high in protein or you only get 10% benefit from the drug? I don't know if that's true, but I'll make sure that I do it in future.....I'm so desperate I'll try anything.

Loz
Posted 11/26/2011 1:10 PM (GMT -5)
My main GERD symptom is nausea on waking. Unless I take my ppi at night it has almost no effect on my reflux. I take it at 9.30 pm and have a small snack shortly after. I don't lie down for at least 2 hours after that to give it time to kick in. I told my doctor I take it at night and they just said that's fine. If I take it during the day it seems to give me no protection at the time I need it most - which is when I'm asleep!

MMM
Posted 11/26/2011 1:51 PM (GMT -5)
The problem I have is I don't know exactly what's causing my reflux? I know I have eosophagities but I don't know what caused it, I don't even know if I have GERD or not? Just a quick question for mudmagnetmum, what ppi are you on, and what strength is it?

Cheers

Loz
Posted 11/26/2011 2:53 PM (GMT -5)
Hey Loz,

I also don't know what causes my reflux. I have morning nausea also, but have never tried taking my PPI at night.

I take 40mg of Nexium first thing in the morning, and then wait at least 30 minutes (usually an hour) before eating. I used to take it after breakfast, but a friend who had also taken it told that her doctor said it was essential to take first thing in the morning, and it actually does help me quite a bit. However, I do still have the morning nausea. I think since my reflux sets in after lunch and/or dinner most of the time, I would have to start taking 2 a day to stop it and frankly, I can't afford that.

Ashley
Posted 11/26/2011 5:13 PM (GMT -5)
I agree, I know I'm not doing it the recommended way but morning nausea and the school run do NOT go well together - so needs must!!

MMM
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