Zoloft at morning, or evening?

Just curious what people have experienced in regard to the timing of taking their AD. I am taking 12.5 of zoloft now, today being day 9. I forgot to bring me K when I was out of town saturday thus I didn't tke it yesterday. I usually take it around 7 a.m. and by lunch am really tired and spaced out. I have to take adderall to counter this, and that only does so much. It is really impacting how I function at my job which of course causes more anxiety. My doc says I can experiment and take my dose in the evening to see, which I will do this coming Thursday (light work schedule on Friday). I keep reading how zoloft peaks 4-5 hours after taking which may explain the timing of the lethargy? If I could get this to help me sleep at night plus eventually help with the GAD it would be a double bonus. Anyway, curious how others have handled tihis. I also know these could be side effects and wear off at some point?

I am scheduled to increase up to 25 mg this Friday.

M.,

Everyone can have a different reaction...so you'll just need to play around with your dosage time to see what works best.

I have read that for some their A/D can be very activating, while other find the same med makes them lethargic!

I hope you can find the 'sweet spot' for yourself...that allows you to sleep well...and be energized when you need to be!

S.C.

I always took it am also.

I have never had a problem with the time of day I take my Zoloft. I currently take mine at night (100 mg).

Technically, it should not matter what time of day you are taking your Zoloft if you are continuously taking it every day. The peak plasma concentration is between 4.5 - 8.4 hours postdose, however, the half-life (the time that it takes to eliminate half the drug from your body) of Zoloft is 26 hours.

So regardless if you take it morning or night, half of the drug is still going to be in your body 26 hours later.

Thank you for all the insightful comments. I plan on taking my zoloft tomorrow evening given that it is the weekend, and if I have a rough night it won't stress me as much with not having to work the next day. I also will increase my dose then from 12.5 to 25. Just wondering what folks experience when increasing their dose....side effects coming back? I really haven't noticed much yet (13 days in) but then again I am on such a small amount I may need to see how the 25 or even 50 mg does for me. I am really hoping that if I take a night it helps me sleep and does something for my GAD. Still having some sleep anxiety and treating that with .5 klonopin per doctors orders. I can add trazadone to that if needed but I don't want to start mixing too many medications. But........no sleep means game over for me in regard to daytime functioning.