Color me ignorant, but the solution is right there in front of us: we are so worried about "over diagnosing" indolent G6 cancer that we are engaging in behaviors that work against diagnosing men with...
Thumbs (and other things) up!...
In fact, try asking this AI about users of (and other info about) healingwell.com -- you may be surprised at the results. The answers to my PCa questions were based on published research, with...
I typed in my PCs history/status and asked for info on salvage therapy. The results were quite good! Djin...
Hi gold horse. The choice of primary therapy is often personal one, but should be based on the entire diagnostic workup : Is his G8 the typical Gleason (4+4) or the less common, but more serious,...
Hi gfspain and Welcome to the Forum! How did you receive your result: was it a report direct from the lab looking exactly like your previous results? Then either it should read 0.070 or they...
I haven't been following this thread, but skimming it earlier, my eyes landed on ChrisR's comment about Labcorp's uPSA test and thought I could add something to (perhaps) lessen some anxiety. The...
Jason, fear not. The critical piece of information from your first post-RP test is actual that your PSA is below 0.1, which means you do not have persistent PSA (which SOC says requires addition...
With regard to Pratoman's comment about doctors accepting a patient's input in decision-making, I think this especially true where SOC doesn't give us hard-and-fast rules (which is generally the...
Hi Patrick. Keep in mind what we all know: we aren't doctors. (Correct me if I am wrong, but I'm assuming your post-RP pT3a staging was because of EPE and not bladder-neck invasion.) Given your...
Hi Hosed and welcome to the Forum! If it helps, I'm pasting my Labcorp uPSA history below. My post-RP nadir was 0.007, so a tad above this test's lowest detectable level, 0.006. I could reach the...
IMO the key to the title is in the word subtypes . Only some men with favorable intermediate-risk or unfavorable intermediate-risk PCa (3+4 or 4+3) have a subtype with cribriform architecture and/or...
Hi slapshot. I, too, have no dog in this fight. However, Morgentaler says "Second, there has been an incorrect assumption that ever-greater androgen concentrations lead to ever-greater PCa growth,...
O'testosterone, where is thy sting? A Urologist's reflection on testosterone and prostate cancer (2024, Comment in The Lancet ) Abraham Morgentaler "In 1941 Huggins and Hodges reported that...
IMO the">" sign in the preprint is a typo for "=" and should read "... intermediate risk (Gleason sum score = 7 , prostate organ-confined, and PSA ˂ 20)..." and, in recapping, the paper does state...
I'm sorry that Danny was dealt a band hand with a complicated diagnosis to boot, but it's encouraging that you are both putting up an excellent fight! On the one hand, it's very good that the...
See also the paper I just linked to: Intermediate risk prostate tumors contain lethal subtypes . If cribriform architecture has been identified, it is no longer intermediate-risk disease. Djin...
A recent paper on cribriform architecture (CA) and intraductal carcinoma (IDC-P). Both are adverse findings in biopsy and RP pathology reports. "The final, formatted version of the article will be...
I asked my uro/surgeon this question and he said that with modern anesthesiology, that's no longer the case. It's rather general health, life expectancy, and the specifics of the case, but he, for...
We don't know. It could be he is a G6 on AS and decided that with the chronic problems of BPH and frequent UTIs, a RP was the best solution. Just one of many possibilities. Djin...
I already spoke about this joke falling flat. I can't get pumped up about it again. Does this ring a bell?...
My take is that someone may have a Favorable Intermediate biopsy score (3+4), but they'd be going on AS not certain whether they actually have Favorable Intermediate cancer . The amounts of tissue...
Hi Paul. Given the importance placed on his biopsy Gleason score for his treatment plan (both the RT and ADT duration), the JH review of his slides could be relevant. I would discuss the value of a...
As mattam says, stick with the same test monthly. You want the repeat testing to give you knowledge about (1) the most accurate knowledge of where your PSA is now; (2) whether there is an upward...
yaamba, Even in this very sad news, your love for, and dedication to, your husband shines through. Thank you, Djin...
Hank and Jeff are college freshmen. Neither can decide between a career in engineering or one in mathematics. They go to see their advisor, who says he'll give them each a two-part test that shows...
Quest calls its most sensitive PSA test "Post-Prostatecomy" (undetectable comes back <0.02). Labcorp calls its most sensitive test "Ultrasensitive" (undetectable comes back <0.006). 1. Whichever lab...
For a robotic RP, I believe it's usually 7-10 days, but sometimes 2 weeks (it was 2 weeks for my open RP)....
Thanks for being a Forum stalwart, Hal !...
Larry, I'll just mention something you probably already know: exercise has been proven to help many who are depressed. Djin...
Patrick, thanks for adding your history. FYI, some years after your RP, in the 8th edition of the TNM Manual, bladder-neck invasion was reclassified from path stage pT2 to pT3a (as in Rick's case)....
Hi Patrick. It would have been best if your doctor had switched you two a 2- or 3- decimal PSA test 6 years ago when you lost your "<" sign. Not only would you have a far more reliable assessment of...
That's great news! -- Here's to the next 10 !!...
From Salvage Therapy for Prostate Cancer: AUA/ASTRO/SUO Guideline Part I: Introduction and Treatment Decision-Making at the Time of Suspected Biochemical Recurrence after Radical Prostatectomy...
Hi Dalota. Sometimes it takes quite a few data points to determine whether you are just fluctuating or a fluctuating but gradually increasing. Remember: there is uncertainty in the right-most digit...
Concurrent antiandrogen therapy in the salvage radiotherapy setting for recurrent prostate cancer: a literature review (2024, Full Text) " Abstract Radical prostatectomy is widely used to treat...
I don't know too much about RT, but my understanding is that there are field widths that lie between fossa-only (narrowest) and whole-pelvis (widest) that, logically, take in an increasing number of...
Next week's meeting of the Clairvoyants Society has been canceled due to unforeseen circumstances....
Thanks for the good-news update, Larry! Djin...
Hi DJac and welcome to the Forum! I'm very sorry to hear about your parents. I wouldn't worry about it being too late--prostate cancer is usually quite slow-growing--if you have it, which you may...
Hi Jason, I'll echo Mumbo: give yourself lots of time to regain your strength and stamina: RP is a major operation; exercise (walking) but don't overdo it. Your signature is fine. A couple of...
"Lymphatic and / or Vascular Invasion Cannot be determined: Focally equivocal Perineural Invasion Present" I read these as separate, the colon being typo for a period: (1) LVI couldn't be determined...
Margin status--positive (cancer cells seen) or negative (none seen)--refers [i]only to the microscopic exam of surfaces of the cuts that the surgeon made to remove your prostate and a small section...
Which reminds me: A poor man in the Old Country is at wit’s end as to how to make a living and is reduced to begging. A friend says to him “Go to America! They say the streets are paved with gold....
That's excellent progress, Jason. Don't be surprised if you leak a little, for example when sneezing, coughing, or even laughing. Did you check your patient portal for your surgery path report? The...
Has your weight gone up the past year? As weight goes up, blood volume goes up, and PSA may go down a bit (and vice versa). A number of intrinsic (you) and extrinsic (the test) factors can go up or...
I personally requested a copy of my original Decipher report (this report doesn't change but I misplaced my original) and a copy of my updated GRID report. The two reports came today as encrypted...
Hi Jay, Let me get back to you on this after I make an inquiry. Thanks, Djin...
Men who have had the Decipher test and are facing a difficult decision about if and when to begin salvage therapy may be interested to know that the company that owns the Decipher test, Veracyte, has...
Congrats on getting surgery behind you, Jason! I'm sure you've had loads of Forum suggestions to help make your recovery go as smooth as possible. Follow all your med team's instructions, walk...